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《The Journal of Clinical Anesthesiology》 2013-01
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Improving hypoxic injury in rat hippocampal slices with isoflurane preconditioning

HAN Chuan-lai, WANG Zhi-ping, JIANG Shan.Department of Anesthesiology,Nanjing Hospital of T.C.M, Nanjing 210001, China  
Objective Microelectrode recording technology was used on hippocampal slices to study the effect of preconditioning with isoflurane on orthodromic population spikes(OPS) and hypoxic injury potential(HIP) during and after hypoxia. Methods Sixty SD rats were randomly divided into control group(group C), experiment control group(group EC), isoflurane preconditioning group(group IP),iNOS inhibitor group(group AG) and iNOS inhibitor + Isoflurane preconditioning group(group IPAG).Both group IP and IPAG was given 3 hours isoflurane inhaling preconditioning. A minoguanidine was intraperitoneally injected in group IPAG and group AG.The hippocampal slices were exposed to 14 minutes hypoxia. Then, the distinct reactions of hippocampal slices OPS and HIP was observed. Results The OPS recovery degree of group IP were significantly better than other groups( P 0.05); The duration of HIP in the IP group was much longer than that in other groups ( P 0.05). But onset time of HIP produced no statistically difference between each group. Conclusion Preconditioning with isoflurane can attenuate the injury of rat hippocampal slice during and after hypoxia, which could be blocked by iNOS inhibitors. Thus, iNOS might play important effects in the protective effect of isoflurane.
【CateGory Index】: R614
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【Citations】
Chinese Journal Full-text Database 1 Hits
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【Co-citations】
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