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《JOURNAL OF CLINICAL DERMATOLOGY》 1994-06
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Effects of penicillamine, chloroquine, dapsone, metronidazole, tetracycline and minocycline on the reactive oxgen species

Zhang Xuejun; Yang Sen; Hu Yue; et ol (Institute of Dermatology, Shanghai Medical University)  
Chemiluminescence(CL) method used to measure: (1)reactive oxgen species(ROS) generated in whole blood polymorphonuclear leukocytes (PMNs) induced by opsonized zymosan; (2) superoxide ( ) induced by Xanthine-xanthine oxidase system; (3) hydroxy radicals(·OH) generated by Vit C-Cu-SO4-zymosan system. We investigated the effects of penicillamine, chloroquine, dapsone, metronidazole, tetracycline and minocycline on ROS generated by PMNs and O,·OH generated in the cell-free system. the results showed that penicillamine, chloroquine, minocycline, dapsone, tetracycline and metronidazole had an effect of inhibiting or scavenging ROS generated in PMNs; minocycline, tetracycline and penicillamine had an effect of scavenging O; and penicillamine had an effect of scavenging ·OH.
【Fund】: 广东顺峰制药厂皮肤科学研究基金
【CateGory Index】: R98
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Tai-Ping,LI Qin, SHI Xue-Gong (Cardiovascular Department of 1st Affiliated Hospital of Anhui Medical University,Hefei 230022);Effect of nifedipine on polymorphonuclear leukocytes oxygen metabolism in coronary heart disease[J];Chinese Pharmacological Bulletin;1993-02
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Halmurat, Abuduaini, Abudureyim, et al Institute of Traditional Uighur's Medicine;studiesonthe Metabo1ic Change of Reactive Oxygen Spedes in Patients with Psoriasis[J];JOURNAL OF XINJIANG MEDICAL UNIVERSITY;1999-01
2 YANG Sen, FENG Yi Rong, ZHANG Xue Jun, HU Yue (Dept of Dermatology, the Affiliated Hospital of Anhui Medical University, Hefei 230022);A study of the effects on reactive oxygen species interfering with tetracyclines[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Wang Taiping, He Zhenyang. Department of Cardiovascular Disease, the First Affiliated Hospital, Anhui Medical University, Hefei;STUDIES ON OXYGEN FREE RADICALS OF LYMPHOCYTE AND POLYMORPHONUCLEAR LEUCOCYTE IN PATIENTS OF CORONARY HEART DISEASE[J];Chinese Circulation Journal;1992-01
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