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Bullous epidermo-necrolysis type of drug eruption─A retrospective study of 43 patients

Wang Xiasheng; Li Shenqiu; Fan Lihua (Institute of Dermatology, Shanghai Medical University)  
Forty three patients with bullous epidermo-necrolysis type of drug eruption over the last 10 years, including 21 males and 22 females,aged 2 to 82 years were studied. The main causative drugs included antibiotics(cephalosporins, penicillin, etc.), antipyretics(analgin, etc.), sulfonamide(SMZ), and anti-gout drug(allopurinol). Almost all of the body surface was involved in 36 cases(83. 7%). Necrolysis was generalised within the first 24 hours in 15 cases. Erosive mucous membrane lesions were present in all except 5 cases. The mortality rate was 25. 6/%. Secondary infection was the main cause of death. A multivariant analysis showed that some factors including ase, extent of necrolysis, serum urea nitrogen level, administration of corticosteroid and secondary infection were correlated with the prognosis. The key points of the treatment for this type of drug eruption are discussed.
【CateGory Index】: R758.25
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