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《JOURNAL OF CLINICAL DERMATOLOGY》 1994-06
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Bullous epidermo-necrolysis type of drug eruption─A retrospective study of 43 patients

Wang Xiasheng; Li Shenqiu; Fan Lihua (Institute of Dermatology, Shanghai Medical University)  
Forty three patients with bullous epidermo-necrolysis type of drug eruption over the last 10 years, including 21 males and 22 females,aged 2 to 82 years were studied. The main causative drugs included antibiotics(cephalosporins, penicillin, etc.), antipyretics(analgin, etc.), sulfonamide(SMZ), and anti-gout drug(allopurinol). Almost all of the body surface was involved in 36 cases(83. 7%). Necrolysis was generalised within the first 24 hours in 15 cases. Erosive mucous membrane lesions were present in all except 5 cases. The mortality rate was 25. 6/%. Secondary infection was the main cause of death. A multivariant analysis showed that some factors including ase, extent of necrolysis, serum urea nitrogen level, administration of corticosteroid and secondary infection were correlated with the prognosis. The key points of the treatment for this type of drug eruption are discussed.
【CateGory Index】: R758.25
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【References】
Chinese Journal Full-text Database 5 Hits
1 NIU Hong-xi GENG Long SHANG Ying-bin XU Yuan-yuan SONG Fang-ji CHEN Hong-duo.Department of Dermatology,First Affiliated Hospital,China Medical University,Shenyang 110001,China;Clinical analysis of 191 cases of severe drug eruptions[J];中华皮肤科杂志;2006-09
2 YANG Bo,ZHANG Mei-hua;Clinical Analysis of the Sensitizing Drugs and Eruption Types of 305 Patients with Drug Eruptions[J];中国皮肤性病学杂志;2006-06
3 WANGXia-sheng;Advances in study of severe bullous drug eruptions[J];临床皮肤科杂志;2004-04
4 Huang Kan. Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, 221002;Clinical analysis of 23 patients with bullous epidermal necrolysis type of drug eruption[J];中国麻风皮肤病杂志;2003-06
5 HUANG Shu-qiong,WANG Lin,ZHANG Min,et al(Dermatology Department,The People Hospital of Leshan China);Clinical analysis of 16 patients with bullous epidermolysis type of drug eruption[J];皮肤病与性病;2002-01
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 CHEN Xiang-qi,LIU Xiang-nong,CHEN Sheng-ping;Clinical Analysis of 141 Cases of Drug Eruptions[J];中国皮肤性病学杂志;2004-05
2 LUO Xiao-qun, WENG Meng-wu(Department of Dermatology, Huashan Hospital, Shanghai Medical University, 200040,China);A clinical review on 79 cases of in-patient with severe drug eruption[J];临床皮肤科杂志;2001-03
3 CHEN Lei, PAN Meng, ZHENG Jie. Department of Dermatology, Ruijin Hospital, Shanghai Second Medical University,Shanghai 200025;The Relationship Between the Prognosis of Allopurinol- Induced Drug Eruption and Renal Function[J];中华皮肤科杂志;2000-02
4 Fang Hong et al(Department dermatology of the First Afficliated Holpial of Zhejiang Medical University);progress of the therpy of toxic epidermal necrolysis (a review)[J];皮肤病与性病;1998-01
5 Wang Xiasheng; Li Shenqiu; Fan Lihua (Institute of Dermatology, Shanghai Medical University);Bullous epidermo-necrolysis type of drug eruption─A retrospective study of 43 patients[J];临床皮肤科杂志;1994-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Chen Yu;Huang Daoqiong;Zhang Ruojin;He Haohao;Hu Ling;Ward 122,the First Affiliated Hospital of Wenzhou Medical University;;Risks analysis and nursing of nosocomial infection in severe drug rush patients[J];中华现代护理杂志;2015-27
2 LIU An;YE Jiang-zhu;WANG Feng-hua;Center for Infectious Diseases,Beijing YouAn Hospital,Capital Medical University;;Drug-induced rash in 188 HIV-1infected/AIDS patients receiving nevirapine-based antiretroviral therapy[J];中国艾滋病性病;2015-04
3 LI Ping;Department of Pharmacy, the First People's Hospital of Huzhou City;;Retrospective analysis of clinical features, sensitization drugs and prognosis related factors of severe drug eruption[J];中国医药导报;2014-15
4 ZHOU Qing*, SHAO Min-hua, SHI He-jian, ZHANG Guo-long, GU Yong, YANG Ting, PU Jie (Dermatological department, Wuxi people's Hospital Affiliated to Nanjing Medical University, Wuxi 214203, China;*Dermatological department,Wuxi Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine, Wuxi 214203,China);A Retrospective Analysis of 23 Cases of Stevens-Johnson Syndrome[J];中国皮肤性病学杂志;2013-08
5 Kang Jian,Zhang Xiaojian and Du Shuzhang(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052);Drug Eruption Inpatients:Analysis of 249 Clinical Cases[J];中国药事;2012-10
6 LU Tao1,LIU Ji-yong2(1.Nanjing Chest Hospital,Nanjing 210029,China;2.Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China);Analysis of treatment of 412 patients with drug-induced cutaneous allergic diseases[J];实用药物与临床;2011-05
7 Han Chunxiang;Ampicillin-induced eruption of care[J];求医问药(下半月);2011-10
8 Sun Liangdan,Zhang Fei,Yang Sen Department of Dermatovenereology,First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Clinical analysis of 26 patients with toxic epidermal necrolysis[J];安徽医学;2011-06
9 WU Fei,ANG Zheng-bing,CHENG Rong,ZHANG Yan-qin Department of Dermatology,Wuhu No.2 People′s Hospital,Wuhu 241001,China;Clinical analysis of 107 cases with drug eruption[J];皖南医学院学报;2011-01
10 CHEN Xiao-mei,CHENG Yan,GUO Zai-pei,ZHANG Min (Department of Dermatovenereology,West China Hospital,Sichuan University,Chengdu 610041,China);Intravenous immunoglobulin treatment of severe drug eruptions compticated with severe skin infections[J];临床皮肤科杂志;2011-02
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