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《Chinese Journal of Clinical Neurosciences》 2018-03
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Plasma Levels and Clinical Significance of Complement Activation Products in Generalized Myasthenia Gravis Patients with Acetylcholine Receptor Antibodies

SONG Jie;YAN Chong;XI Jian-ying;LU Jia-hong;ZHAO Chong-bo;Department of Neurology,Huashan Hospital,Fudan University;  
Aim To investigate the plasma levels of complement activation products(C3 a,C5 a and s C5 b-9) in patients with generalized myasthenia gravis(MG) before and after immunotherapy and analyze their clinical significance.Methods Plasma samples of 40 generalized MG patients with acetylcholine receptor(ACh R) antibodies were collected before immunotherapy and 4~6 months after the treatment from August 2015 to May 2017 in Huashan Hospital.Forty unrelated healthy blood donors were enrolled as healthy controls.Plasma concentrations of C3 a,C5 a and s C5 b-9 were measured by ELISA method.The differences between the two groups were compared.The relationships among plasma complement activation products levels and Quantitative Myasthenia Gravis(QMG) scores,Manual Muscle Test(MMT) scores and ACh R antibody titers were also analyzed.Results The concentrations of C3 a and s C5 b-9 in MG patients were significantly higher compared with the normal controls.There was no significant difference in C5 aconcentrations between the two groups.The concentrations of C3 a,C5 a and s C5 b-9 in MG patients were significantly decreased after immunotherapy(P0.01).The plasma level of C3 a in MG patients before immunotherapy significantly correlated with the QMG scores(r=0.57,P0.01) and MMT scores(r=0.38,P=0.03).No correlations were found between plasma concentrations of C3 a,C5 a,s C5 b-9 and ACh R antibody titers.Conclusion Plasma levels of complement activation products are elevated in MG patients and they are decreased after the immunotherapy.Plasma level of C3 a might be a potential useful biomarker in assessing disease severity of MG.
【Fund】: 国家精准医学重大专项罕见病临床队列研究(编号:2016YFC0901504)
【CateGory Index】: R746.1
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