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《Practical Clinical Medicine》 2000-01
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Study on Cognition in childhood Epilepy

CAI Lanyun,ZHOU Mozi,DENG Yunzhu,XU Shujuan,LI wuijun,WANG Ruilan (1.Department of Neurology,Jiangxi Children's Hospitol,Nanchang 330006,China; 2.Departmen of Children's Health,Jiangxi Children's Hospitol,Nanchang 330006,China; 3.Department  
Objective:To study the effects of Phenobarbital (PB) and Carbamazepine (CBZ) on cognition in childhood epilepsy.Methods:The patients diagnosed primary tonic-clonic seizures without obvious mental retardation were chosen and randomly assigned to either PB group (29 patients) or CBZ group (25 patients).The normal control group was also established. WISC-CR、WPPSI、SLPS(Scale of social adaptation ability of infant-junior middle school student)P300 and questionatives were used for the assessment before and after 6 months of treament.Results:The FSIQ of epilepsy grous was obviously lower than control group before treatment.(The rate of FSIQ80 was 51.9% and SLPS9 was 33.3% in epilepsy groups while it were 0 and 5.60% in control group.Prolonged P300 latency was 30% in the epilespsy groups.FSIQ,PIQ,VIQ,and P300 latency were not significant different between the first and the second tests in all three groups ( P 0.05).Conclusions:With the routine dosage therapy,PB and CBZ don't remakebly affect the cognition in childhood epilepy.Therefore the regular drug is recommended.)
【CateGory Index】: R742.1
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