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《Practical Clinical Medicine》 2003-01
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Bacteria of Nosocomial Pulmonary Infection in Intensive Care Unit

Luo Fo quan 1, Fu Hua qun 2 (1.Department of ICU,First Affiliated Hospital of Jiangxi Medical College, Nanchang 330006,China;2.Department of General Surgery,Second Affiliated Hospital of Jiangxi Medical University, Nanchang 330006,China)  
Objective: To study the causative organisms and the drug resistance of nosocomial pulmonary infection(NP)in intensive care unit(ICU).Methods:The morbidity of NP in 203 patients who had stayed in ICU for 3 days or more during the period from July 2000 to July 2002 was analyzed retrospectively. The pathogens'spectrum and their resistance profiles were analyzed also. Results: Among the 203 patients,53 of them developed nosocomial pulmonary infection once at least and the morbidity was 26.1%(53/203).The hospitalization time was directly related to the morbidity (r=0.39, P 0.01).In 135 strains of pathogens from 39 of 53 NP patients, the percentage of G - bacteria,G + bacteria, and fungi were 69.6%,23%,and 7.4% respectively.Among all the pathogens,Pseudomonas aeruginosa was the most predominant,Staphylococcus aureus was the second one, followed by Escherichia coli,Klebsiella Pneumoniae,Acinetobacter baum/haemolyticus and Enterobacter cloacae in turn. 50 of 125 strains of bacteria produced ESBL.The percentage was 42.4%.But there was no statistically significant difference between the two percentages to produce ESBL.Most of the bacteria were multiple resistant to the tested antimicrobial. Vancomycin, Rifampin,Tetracycline, and SMZ TMPCo were relatively sensitive to the G + bacteria and all the other tested antimicrobial worked extremely poor on them.The relatively effective antibiotics against G -bacteria mainly including Amikacin,Aztreonam,Ceftazidime,Imipenem,and Piperacillin/Tazobactam.These G -bacteria showed highly resist to the other tested antimicrobial.Conclusion:The morbidity of NP was relatively high in ICU,G -bacteria was the dominant causative pathogens.Among all the pathogens,the pseudomonas aeruginosa was the most major one, following it was staphylococcus aureus. Most of the pathogens were multiple resistant.ESBL production is one of the major causes.
【CateGory Index】: R563.1
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