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《Practical Clinical Medicine》 2003-01
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Testing of Endotoxin,Interleukin-6 and Interleukin-8 in Patients with Cirrhosis

Wu Da jun, Zeng Hao, Liu Jun (Department of Gastroen terology,First Affiliated Hospital of Jiangxi Medical College, Nanchang 330006,China)  
Objective:To explore the relationship of the levels of plasma endotoxin, interleukin 6(IL 6),and interleukn 8(IL 8)with pathogenesis in patients with cirrhosis due to HBV Hepatitis.Methods: Levels of plasma endotoxin,IL 6 and IL 8 were detectec by limulus assay and ELISA respectively in 64 patients and 20 controls.Results:Endotoxin, IL 6 and IL 8 levels were higher in the patients than those in controls( P 0.001). There were significant correlations among endotoxin,IL 6 and IL 8 levers.Endotoxin, IL 6 and IL 8 levels in cirrhosis increased with worsening of Child score.Conclusion:Endotoxin,IL 6 and IL 6 may play important roles in the pathogenetic process of the cirrhosis.Endotoxin,IL 6 and IL 8 may participate in the development and/or maintenance of hyperdynmic circulation and portal hypertension.
【CateGory Index】: R575.2
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