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《Chinese Journal of Clinical Medicine》 2006-01
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Effect on Endothelial Function by C pneumoniae Infection in Workers Exposed to Acrylonitrile

BAI Yongyi YU Zhuyuan XU Jian et al.Department of Cardiology,Jinshan Hospital,Fudan University, Shanghai 200540  
Objective: To explore effects on endothelial function by C pneumoniae in workers exposed to acrylonitrile. Methods:111 workers exposed to acrylonitrile were recruited and their blood specimens were collected for determining the levels of metabolites of nitric oxide(NOX).as well as the activities of total nitric oxide synthetase(tNOS)and inducible nitric oxide synthetase(iNOS). At the same time, C pneumoniae specific antigen in the peripheral blood mononuclear cell and plasma specific antibodies (IgA, IgG and IgM) to Cpn were measured by microimmunofluorescence test. Results: Serum levels of NOx was significantly lower in the Cpn-Ag positive group and Cpn- IgM positive group than those in the accordingly negative groups(P 0.05). By means of stepwise multivariate linear regression, positive of Cpn-Ag and Cpn- IgM were main factors affecting serum levels of NOX (P0.05). Conclusion:Cpn infection could cause damage to the endothelial function of workers exposed to acrylonitrile.
【CateGory Index】: R363
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Chinese Journal Full-text Database 2 Hits
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Chinese Journal Full-text Database 10 Hits
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