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《Chinese Journal of Clinical Medicine》 2006-01
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The Correlation Factors Analyses of COPD Complicated by CI in Acute Exacerbation Time

SUN Jiayuan XU Bin ZHOU Yagang,et al.(The Fifth People's Hospital of Shanghai,Fudan University,Shanghai 200240  
Objective: To analy the indexes differences that reflected prethrombotic states and pulmonary function between COPD (chronic obstructive pulmonary disease) and COPD complicated by CI(cerebral infarction ),and to provide prevention and treatment evidences of COPD complicated by CI . Methods:All study subjects included COPD complicated by CI group , COPD group, acute bronchitis group. Hood gas, pulmonary arterial systolic pressure(PASP), endothelin-1, atrial natriuretic peptide, prothrombin time, thrombin time, activated partial thromboplastin time, fibrinogen, antithrombin-Ⅲ(AT-Ⅲ), D dimer(D-D),tissue plasminogen activator, plasminogen activator inhibitor-I were observed, Meanwhile,control study and correlation analyses were executed . The clinical feature and head CT/MRI appearance also were analyzed in the COPD complicated by CI group. Results: Compared with simple COPD patients, the patients of COPD complicated by CI had lower AT-Ⅲ (234.39±39. 66 vs 278. 90±53. 01, P0.01), higher D-dimer and PASP(2. 25±2.07 vs 0. 87±0. 61 ,P0.01(42. 50±17. 67 vs 32. 48±15. 52 ,P0. 05). Futhermore, correlation existed among them in the group of COPD complicated by CI group. There were 15 chronic heart failure ( CHF ) patients and 37 lacunar infarction patients in COPD complicated by CI. Conclusion: AT-Ⅲ,D-D,PASP can be served as evidences for diagnosing and prophylactic treatment for patients of COPD complicated by CI. To prvent the occurrence of COPD complicated by CI,anticoagulant therapy and controling pulmonary arterial pressure should be done in time if there are features above mentioned in COPD patients.
【Fund】: 上海市闵行区科技发展基金资助(04-79)
【CateGory Index】: R563.9;R743.3
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