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《Chinese Journal of Clinical Medicine》 2006-01
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PGL1,a Candidate Metastatic Suppressor Gene of Human Hepatocellular Carcinoma

LEI Kefeng WANG Yanfang ZHU Xiaoqun et al Liver Cancer Institute,Zhongshan Hospital,Fudan University,Shanghai 200032  
Objective:To screen and identify the genes relating to the metastasis of human hepatocellular carcinoma (HCC). Methods:The difference of gene expression profiles between the HCC tissue with and without metastasis were analyzed by oligo nucleotide microarray. Based on the findings of this gene expression profiling and the previous molecular cytogenetic studies, the leading differently expressed genes were identified and selected for further analysis by semi-quantitative RT-PCR. Results: 989 differently expressed genes were detected between the HCC tissues with and without metastasis. One of the leading candidate genes on chromosome 8p, FGL1, was identified. And RT-PCR analysis demonstrated that FGL1 gene was significantly down-regulated in the HCC tissues with metastasis, which further confirmed the results of the gene chips technique. Conclusion: The gene expression profiles were significantly different between the HCC tissues with and without metastasis. FGL1 on chromosome 8p might possess metastasis suppressor activity in HCC.
【Fund】: 国家杰出青年基金(30325041) 国家863计划重点项目(2002BA711A02-4) 教育部跨世纪优秀人才培养计划(教技函2002-48) 教育部重大项目(教技司2001-171)。
【CateGory Index】: R735.7
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