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《Chinese Journal of Clinical Medicine》 2006-01
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Investigation of the Granzyme B within Hepatocellular Carcinoma and Cirrhosis Tissues

CHEN Gang LUO Dianzhong GUO Fang, et al.Department of Pathology, Guangxi Medical University,Nanning 530021  
Objective:To investigate the expression of granzyme B(GrB) in hepatocellular carcinoma(HCC), paraneoplastic, cirrhosis and normal liver tissues and the relationship between GrB+ lymphocytes and HOC patients situation in clinic. Methods: Surgical specimens from 60 cases of HOC, 62 cases of cirrhosis and 23 cases of normal liver tissues were investigated by immunohistochemical staining of GrB with polymer detection system. Results:①The order of the number of GrB+ cells from the highest to the lowest was: paraneoplastic, HOC, normal liver and cirrhosis tissues; ②There was no relationship between the number of GrB+ cells in HCC and its histological grade;③The number of GrB+ cells in the cases with metastasis in 15 months was significantly lower than that without metastasis;④The number of GrB+ cells in HCC deaeased with the clinical TNM stage;⑤There was no statistical difference between the data of AFP group progress of negativebefore operation and that of positive;⑥The number of GrB+ cells of HBsAg positive group was higher than that of the negative one in cirrhosis and paraneoplastic tissues; There was no relationship between the number of GrB+ cells and HBsAg in HCC;⑦There was no statistical difference between the data of the group with cirrhosis and that without cirrhosis in paraneoplastic tissues. Conclusion:The number of GrB+ cells decrease with the progress of the HOC patients in clinic. The number of GrB+ cells is closely related to HBsAg, meanwhile it possess no relevance to the pathological grades, AFP level and cirrhosis. The number of GrB+ cells might be an important marker to estimate the local immune status and a useful factor to predict the prognosis of HCC patients.
【Fund】: 广西科学基金资助(合同编号:桂科0342021)
【CateGory Index】: R735.7;R575.2
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