Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Medicine》 2006-01
Add to Favorite Get Latest Update

Investigation of the Granzyme B within Hepatocellular Carcinoma and Cirrhosis Tissues

CHEN Gang LUO Dianzhong GUO Fang, et al.Department of Pathology, Guangxi Medical University,Nanning 530021  
Objective:To investigate the expression of granzyme B(GrB) in hepatocellular carcinoma(HCC), paraneoplastic, cirrhosis and normal liver tissues and the relationship between GrB+ lymphocytes and HOC patients situation in clinic. Methods: Surgical specimens from 60 cases of HOC, 62 cases of cirrhosis and 23 cases of normal liver tissues were investigated by immunohistochemical staining of GrB with polymer detection system. Results:①The order of the number of GrB+ cells from the highest to the lowest was: paraneoplastic, HOC, normal liver and cirrhosis tissues; ②There was no relationship between the number of GrB+ cells in HCC and its histological grade;③The number of GrB+ cells in the cases with metastasis in 15 months was significantly lower than that without metastasis;④The number of GrB+ cells in HCC deaeased with the clinical TNM stage;⑤There was no statistical difference between the data of AFP group progress of negativebefore operation and that of positive;⑥The number of GrB+ cells of HBsAg positive group was higher than that of the negative one in cirrhosis and paraneoplastic tissues; There was no relationship between the number of GrB+ cells and HBsAg in HCC;⑦There was no statistical difference between the data of the group with cirrhosis and that without cirrhosis in paraneoplastic tissues. Conclusion:The number of GrB+ cells decrease with the progress of the HOC patients in clinic. The number of GrB+ cells is closely related to HBsAg, meanwhile it possess no relevance to the pathological grades, AFP level and cirrhosis. The number of GrB+ cells might be an important marker to estimate the local immune status and a useful factor to predict the prognosis of HCC patients.
【Fund】: 广西科学基金资助(合同编号:桂科0342021)
【CateGory Index】: R735.7;R575.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Tang Yangbo, Tan Yizhou, Zhang Huizhong, et al. Institute of Infectious Diseases, The Eighth Hospital, Guangzhou 510060;Hepatitis viruses in hepatocellular carcinoma[J];Guangdong Medical Journal;2001-04
2 Qiu Dapeng Qiu Shuangjian Wu Zhiquan, et al. (Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032);Investigation of the Distribution and Local Immunology of NKT Cells within Hepatic Cancer Tissue[J];Clinical Medical Journal of China;2004-04
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 YANG Jie~(1,2),FAN Huahua~2,NIE Xiaoxuan~2,GAO Li~2,LIU Yan~2,ZHANG Ping~1,GAO Feng~2.1.Immunology Laboratory,Life Science Department,East China Normal University,Shanghai 200062,China;2.Blood Engineering Laboratory,Shanghai Blood Center,Shanghai 200051,China;A comparative study on the biological characteristics of Vα24 NKT cells and CD3~+CD56~+CIK cells from human peripheral blood[J];Chinese Journal of Blood Transfusion;2006-05
2 Rong-Shan Fan,De-Rong Sun,Department of Internal Medicine, the Second Hospital of Daqing City, Daqing 163461, Heilongjiang Province, China De-Jun Yu, Department of Laboratory, the Second Hospital of Daqing City, Daqing 163461, Heilongjiang Province, China;Numbers and activities of CD56~+T cells and natural killer cells in cirrhotic livers with hepatitis C[J];World Chinese Journal of Digestology;2006-18
China Proceedings of conference Full-text Database 1 Hits
1 Xiao Gang Huang,Yi Su,Shi De Lin.Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China;Vα24 NK T cells in peripheral blood and their correlations with the severity of hepatic injury in patient with chronic hepatitis B virus infection[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LIAO Huiyu, LANG Zhenwei, ZHU Renping, et al. Youan Hospital, Beijing 100054;A study of HGV infection in liver tissue of hepatocellular carcinoma[J];CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY;1999-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved