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《Chinese Journal of Clinical Medicine》 2006-01
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The Effect of NM-3 on Cells Proliferation and Apoptosis of the Human Gastric Cancer Cell SGC-7901 in vitro

LI Qin ZHU Jinshui Department of Gastroenterology, Shanghai Jiaotong University Affiliated Shanghai Sixth People's Hospital, Shanghai 200233  
Objective: To study the action of NM3, which is a kind of angiogenesis inhibitor, on the growth and apoptosis of human gastric carcinoma cell line SGC-7901 and discuss its action mechanism. Methods:Human gastric carcinoma cell line SGC-7901 was treated with NM-3, Carboplatin and NS Cell proliferation was evaluated with MTT assay, Distributions of cell cycle and apoptosis rate were determined with flow cytometry, cell apoptosis was confirmed by morphology. Results:The inhibition effect of NM-3 was not apparent on the proliferation of SGC-7901 compared with controls, the apoptosis rate was not statistically different (P0. 05). In cell cycle analysis, NM-3 could not increase the proportion of cells in the G0/G1 phase which was an indication of early apoptosis. Conclusion:NM-3 could not induce the apoptosis of human gastric cancer cell SGC-7901 in vitro, it enhanced the sensitivity of Carboplatin on human gasric cancer cell SGC-7901 in vitro. It had no direct effect on proliferation of gastric carcinoma cells. The anticancer mechanism of NM-3 in animal model was mainly related to its antiangiogenesis action.
【Fund】: 上海市自然科技基金项目(022B14072)
【CateGory Index】: R735.2
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