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《Chinese Journal of Clinical Medicine》 2006-01
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Clinical Analysis of Cryptococcal Meningitis in Systemic Lupus Erythematosus

LU Liangjing LU Fanglin BAO Chunde, et al.Department of Rheumatology,Reji Hospital,Shanghai Second Medical University ; Shanghai Institute of Rheumatology, Shanghai 200001  
Objective:To study the characteristic,diagnosis and therapeutics of cryptococcal meningitis (CM) associated with systemic lupus erythematosus (SLE) and to improve the relevant diagnostic and therapeutics of the disease. Methods:8 patients with SLE, complicated by CM had been included in the study. The data of clinical manifestations,cerebrospinal fluid(CSF) findings and the whole process of diagnosis and treatment were reviewed. Results: The complication in SLE was always clinically latent. The nonspecific clinical and CSF laboratory findings may lead to misdiagnosis such as lupus encephalopathy or tuberculous meningitis. In our patients, the period from initiation of disease to diagnosis definitely was about 2-16 weeks. The rate of misdiagnosis was 50%. Timely and repeatedly CSF cryptococcus latex agglutination, culture or smear is the key to diagnosis. Antifungal therapy mainly with amphotericin B was effective and the efficiency was 100%. Conclusion:The early diagnosis and effective antifungal therapy could remarkably improve the prognosis of cryptococcal meningitis in SLE patients.
【Fund】: 上海市重点学科建设项目资助课题(T0203)
【CateGory Index】: R593.241;R519
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1 GU Ju-lin,WEN Hai,CHEN Jiang-han,CHEN Yu-chong,LI Jun-cheng(Department of Dermatology,Changzheng Hospital,the Second Military Medical University,Shanghai 200003,China);A clinical study of the 39 cases of cryptococcal meningitis[J];Journal of Clinical Dermatology;2005-12
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