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《Chinese Journal of Clinical Medicine》 2006-02
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The Distribution of Foam Cells Derived from Dendritic Cells in Atherosclerotic Plaque of Rabbit Model

SHI Hongyu ZHANG Hongqi SUN Aijun,et al.Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai 200032  
Objective:To investigate whether of foam cells might be derived from dendritic cells and their distribution in atherosclerotic plaque of rabbit model. Methods: Aortas were acquired from high-fat diet induced atherosclerotic rabbit model and underwent immunohistochemical investigations and electronmicroscopic examination. A monoclonal anti-S-100 antibody was used to identity foam cells derived from dendritic cells, and electron microscopy were used to observe the ultrastructure of these cells. Results: No cells expressing S-100 were observed in the intima of normal artery. Cells expressing S-100 were present around foam cell-rich areas within intimal atherosclerotic lesions in atherosclerotic artery and some displayed typical appearance of foam cells. Electron microscopy demonstrated that some of dendritic cells have a large number of lipid droplets filled in their cytoplasm, and exhibit the typical characteristics of foam cells. Conclusion: Our results demonstrated that dendritic cells might be a new source of foam cells in atherosclerotic plaque, which may be of great importance in atherosclerosis.
【Fund】: 国家重点基础研究发展规划资助项目(G2000056903) 上海市科委资助项目(02JC14026)
【CateGory Index】: R543.5
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