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《Chinese Journal of Clinical Medicine》 2006-02
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Effect of Atorvastatin on Protection of Vessel after Balloon Injury

CUI Yan QIU Li XIE Chunyi,et al Department of Cardiology,Shanghai Traditional and Chinese Medicine Integrated Hospital,Shanghai 200082  
Objective:To observe the effects of Atorvastatin on neointimal proliferation of carotid after Ballon Injury in rats. Methods:24 healthy male SD rats were divided randomly into three groups: group of control(C), group of Balloon Injury (BI), and group of balloon injury plus Atorvastatin (10mg/kg·d)(BI+A). It was given by gavage from 3days before to 42 days after balloon injury. And then the pathomorphological examination was carried out and intimal thickness was analyzed by the computer imaging analysis system. The levels of malonyldialdehyde ( MDA),superoxide dismutase (SOD),type Ⅰ procollagen carboxyl terminal peptide (PIP) and oxidized low density lipoprotein (ox-LDL) were measured by biochemistry and ELISA Results: The intimal thickness,the levels of MDA、PIP and ox-LDL in the ballon injury group were higher than those in the group of control,but the SOD is lower. The intimal thickness,the levels of MDA,PIP and ox-LDL in the medical treatment groups were lower than those in the ballon injury group,but the SOD is higher. Conclusion:These results suggest that artery balloon injury may induce increase of biological activity, which can be inhibited by Atorvastatia
【CateGory Index】: R96
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