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《Chinese Journal of Clinical Medicine》 2006-02
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The Clinical Value of Noninvasive Ventilation in Chronic Hypercapnic Respiratory Failure——a 3-Year Retrospective Study

SHE Jun SHEN Ce FAN Lihong,et al.Shanghai Sixth People's Hospital Affliated to Jiaotong University,Shanghai 200233  
Objective: To study the effect of noninvasive positive-pressure ventilation (NIPPV) in treatment of chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease,obesity-hypoventilation syndrome and bronchiectasis. Methods:From 2002 to 2005,there were 116 patients with obstructive pulmonary disorders ,19 patients with obesity-hypoventilation syndrome and 46 patients with bronchiectasis were treated in shanghai No . 6 Hopital because of hupercapic respiratory failure, their clinical data were analyzed respectively. All patients were not treated by NIPPV firstly in terms of chronic hyper-capnic respiratory failure; But at the second time these inpatients were treated by NIPPV. Given pulmonary function , arterial blood gas and calculated the hospitalization dates. Results: (1)Patients had the high probability of pursuing NIPPV, the compliance rate was high (compliance rate. 91 % ). (2)The date of arterial blood gas levels were improved. The arterial PaCO2 decrease from 62±10 mmHg to 53±6 mmHg in chronic obstructive pulmonary disease( P0.01);PaCO2 from 52±10 mmHg to 42±7 mmHg in obesity-hypoventilation syndrome( P0. 001); PaCO2 from 56±6 mmHg to 44±10 mmHg in bronchiectasis(P0.005). Meanwhile the arterial PaO2 increase from 61±13 mmHg,60±12 mmHg,58±11 mmHg to 71±15 mmHg,71±11 mmHg,75±18 mmHg in the three groups respectively( all P0.001). (3)Hospitalization dates decreased in all groups after initiating NIPPV, when compared with the year before NIPPV (P0.05). Conclusion: Noninvasive ventilation has partly effect on chronic obstructive pulmonary disease, obesity-hypoventilation syndrome and bronchiectasis .
【CateGory Index】: R563.8
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