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《Chinese Journal of Clinical Medicine》 2006-02
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Research on the Relationship between Pressure Volume Curves and Morphology of the Lung in Acure Respiratory Distress Syndrome Dogs

XU Yunjie ZHU Lei Department of Emergency,Zhongshan Hospital,Fudan university,Shanghai 200032  
Objective: To evaluate the variation of the lung volume in acute respiratory distress syndrome (ARDS) dogs when PEEP set at levels of different inflection points on the pressure volume(P-V) curves. Methods: The super-syringe technique was used to obtain the deflation and inflation limb curves and the inflection points of the curves were ascertained, then scanned with computed tomography(CT) morphology, also the lung volume when PEEP set at different levels were calculated. Results: (1)The pressure of the point of maximum curvature of deflation limb(PMC,d)was higher than the lower inflection point (LIP) (10.67±0. 82cmH2O vs 8. 77±0. 88 cmH2O, P0. 05). (2) Aerated lung tissue was increased, whereas poorly aerated and nonaerated lung tissue was decreased when PEEP was set at 0, LIP, PMC.d, and UIP, all changes had significant statistic difference. At PLIP and PPMC,d,volume of normally aerated parenchyma was 403.16±12.6 cm3 and 469. 96±13.7 cm3, respectively(P0. 05), hyperinflated lung volume was similar(P0.05). With PEEP increased to PUIP, volume of normally aerated parenchyma was further increased, but hyperinflated lung volume was also increased significantly. Conclusion: These results support the use of PMC,d on deflation limb of the P-V curve for PEEP setting which is more valueable than traditional PEEP set at LIP.
【CateGory Index】: R563.8
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【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 HOU Jing-jing,ZHU Lei,NIU Shan-fu,SHENG Hua,XU Yun-jie,ZHU Du-ming. Department of Respiratory Medicine,Zhongshan Hospital,Medical Institute of Fudan University,Shanghai 200032,China;Effects of oxygen indexes on the diagnosis of acute lung injury[J];Chinese Journal of Emergency Medicine;2006-11
2 ZHU Lei, LI Yan qin, ZHANG Zhi feng, NIU Shan fu (Institute of Respiratory Disease,Fudan University-Department of Pulmonology,Zhongshan Hospital, Fudan University, Shanghai 200032);Pressure-Volume Curve of Dogs with Acute Lung Injury[J];Journal of Shanghai Medica(University);2001-06
3 SHENG Hua, ZHU Lei, XUYunjie, CAI Yingyun, ZHU Huili, NIU Shanfu. Department of Respiratory Medicine , Hua-dong Hospital, Shanghai 200040, China;Inflation and deflation limbs of pressure-volume curves in acute respiratory distress syndrome dogs[J];Shanghai Medical Journal;2006-05
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 HOU Jing-jing,ZHU Lei,NIU Shan-fu,SHENG Hua,XU Yun-jie,ZHU Du-ming. Department of Respiratory Medicine,Zhongshan Hospital,Medical Institute of Fudan University,Shanghai 200032,China;Effects of oxygen indexes on the diagnosis of acute lung injury[J];Chinese Journal of Emergency Medicine;2006-11
2 SHUN Dejun,YANG Jingping,XU Xiyuan,et al.Department of Respiratory and Critical Care Medicine,The Third Affiliated Hospital of Inner Mongolia Medical College.Baotou,Inner Mongolia 014010,China;The application of dynamic pressure-volume curve in patients with acute respiratory distress syndrome[J];Chinese Journal of Respiratory and Critical Care Medicine;2005-06
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