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《Chinese Journal of Clinical Medicine》 2006-02
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Serum Concentrations of Tumor Markers in Patients with Chronic Kidney Disease

YU Xiao fang JIANG Yang YE Zhibin Department of Nephrology,Zhongshan Hospital,Fudan University,Shanghai 200032  
Objective: Increased serum tumor markers strongly indicate the diagnosis of the corresponding tumor. We studied the effects of Creatinine Cleareace (Ccr) on the serum concentrations of some tumor markers such as CEA, CA199, CA125, AFP, PSA and fPSA in patients with chronic kidney disease. Methods: The serum concentrations of those tumor markers in 232 nondialysis patients with chronic kidney disease were tested. These patients were divided into three groups according to their Ccrlevel: Ccr≤25ml/min group, 25ml/minCcr50ml/min group and Ccr≥50ml/min group. Male patients were also divided into three groups to test PSA and fPSA. Results: The serum levels of CEA and CA199 in different Ccr groups had significant statistical differences and also had negtive correlations with Ccr. There was no difference in CA125, AFP, PSA and fPSA among the three groups. Conclusion: The diagnostic value of serum CEA, CA199 and CA125 for the corresponding tumors are lower in patients with severely damaged kidney function than those with normal or mildly reduced renal function.
【CateGory Index】: R692
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Chinese Journal Full-text Database 1 Hits
1 ZHANGYue YE Zhibin JI J un (Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032);Serum Levels of Four Tumour Markers in Primary Kidney Disease Patients[J];Clinical Medical Journal of China;2005-01
Chinese Journal Full-text Database 2 Hits
1 YU Xiaofang, XU Xialian, YE Zhibin, WU Zhaolong. Department of Nephrology,Zhongshan Hospital. Fudan University , Shanghai 200032, China;Serum concentrations of tumor markers in diaiyzed and non-dialyzed patients with chronic kidney diseases[J];Shanghai Medical Journal;2007-02
2 CHEN Hui-le,JIN Ling-wei, MAO Chao-ming. Department of Nephrolog, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China.;Effects of damaged kidney function and hemodialysis on serum concentrations of tumor markers[J];The Journal of Practical Medicine;2008-04
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