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《Chinese Journal of Clinical Medicine》 2006-02
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Expression of Vascular Endothelial Growth Factors and Thrombospondin-1 in Bladder Transitional Cell Carcinoma

ZOU Ge YANG Luoyan LIU Ziting,et al.Department of Urology Surgery,People's Hospital of Panyu,Guangzhou 511400  
Objective: To investigate the expression of Vascular Endothelial Growth Factors (VEGF),Thrombospondin-1 (TSP-1)and its relationship with angiogenesis in bladder Transitional Cell Carcinoma(TCC). Methods: Both expression of VEGF and TSP-1 were assayed using immunohistochemical technique in 48 cases of primary TCC and 10 cases of healthy urocystic tissue,and comparisons between them were made, microvessel density(MVD)of tumor tissue was also measured. The correlation among VEGF, TSP-1 and MVD , and their relations with pathological grading and clinical stages for the tumor of bladder were analyzed. Results:It revealed that the expression of VEGF, TSP-1 and MVD strongly linked to pathological grading and clinical stages for the tumor of bladder. In bladder tumor , the high expression level of VEGF was tightly concerned with high value of MVD, while the high expression level of TSP-1 was correlated with low value of MVD(P 0. 05). The carcinoma with moderate or high expression level of VEGF and negative expression of TSP-1 correlated with high mean of MVD, which was contrary in the case of mild expression level of VEGF and positive expression of TSP-1. When took moderate expression level of VEGF as a premise, low expression level of TSP-1 companied with high value of MVD, while high expression level of TSP-1 corresponded with low value of MVD(P 0.05). Futhermore, the expression of VEGF, TSP-1 was related to the postoperative recurrence(P 0.05). Conclusion: The expression of VEGF, TSP-1 is related to the occurrence and development of bladder TCC. it is the major cause of bladder tumor angiogenesis. The measurement of VEGF, TSP-1 can be used as a significant index of diagnosing prognosis for bladder TCC patients. Treating the tumor of badder by anti- angiogenesis from all aspects maybe more effective.
【CateGory Index】: R737.14
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