Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Medicine》 2006-02
Add to Favorite Get Latest Update

The Experiment Study on Apoptosis-inducing Effect of Arsenic Trioxide (AsO_2) on Canine Iliac Artery Smooth Muscle Cell

CHEN Peng WANG Jianhua HU Meiyue Department of Radiology,Central Laboratory,Zhongshan Hospital,Fudan University,Shanghai 200032  
Objective:To study the possible apoptosis-inducing effect of arsenic trioxide(AsO2)on canine artery smooth muscle cell. Methods: A wide range concentration of arsenic trioxide were cultured with (vascular smooth muscle cell.VSMC) with different time,cell growth curve, MTT assay, electron microscopy detection, inverted phase contrast microscope, HE staining were used to study cell activity and morphologic changes. Results: After culturing with AsO2, VSMC present cells number decrease,fat granule increase,and apoptotic featuresect. Electron microscopic appearance of VSMC exhibiting membrane integrity, chromatin condensation,apoptotic body formation,ect. Conclusion:AsO2 can induce apoptosis of VSMC
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Li Hui,Zhang Yanbin,Song Hao,Xiao Fei,Zhang Zhuoqi,Li Dongye.West China Second Hospital,Sichuan University,Sichuan 610041,China;Study on the Mechanisms of Arsenic Trioxide-induced Vascular Smooth Muscle Cells Apoptosis in vitro[J];Journal of Medical Research;2010-10
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 YU Zhiyong,WANG Shuguang,QIN Hongjun,and LI Kun.Hepatobiliary Surgery Institute of PLA,Xinan Hospital,The Third Military Medical University,Chongqing 400038,Ch ina;Arsenic trioxide induces apoptosis in HUVECs and inhibits angiogenesis in CAM[J];Medical Journal of the Chinese People's Armed Police Forces;2004-01
2 XING Mao 1, ZHANG En-Juan 1, YE Xin 2 ( 1Dept of Pharmacy, 2Dept of Oncology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037);Investigation of the pathway of apoptosis induced by arsenic trioxide in cancer cells[J];Chinese Pharmacological Bulletin;2002-01
3 Zhao Pu.Department of Hematology,Third Affiliated Hospital of Wenzhou Medical College,Zhejiang 325200,China;Study of Sodium Arsenite in Treating 30 Cases of Adult Chronic Myeloid Leukemia[J];Journal of Medical Research;2008-12
4 He Liya,Lai Dongbo,Tong Lizhen.Guangzhou Children's Hospital,Guangdong 510120,China;Clinic Analysis of Childhood Acute Non-lymphocytic Leukemia[J];Journal of Medical Research;2009-05
5 YANG Wei~*, GE Jun-bo, LIU Hong-ling, AN Yi, LIU Xue-bo,TIAN Ye, QU Xiu-fen, LI Wei-min, HUANG Yong-lin. * The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China;Arsenic trioxide eluting stents to prevent restenosis of injured iliac arteries in rabbits[J];Chinese Journal of Cardiology;2006-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved