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《Chinese Journal of Clinical Medicine》 2006-02
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The Experiment Study on Apoptosis-inducing Effect of Arsenic Trioxide (AsO_2) on Canine Iliac Artery Smooth Muscle Cell

CHEN Peng WANG Jianhua HU Meiyue Department of Radiology,Central Laboratory,Zhongshan Hospital,Fudan University,Shanghai 200032  
Objective:To study the possible apoptosis-inducing effect of arsenic trioxide(AsO2)on canine artery smooth muscle cell. Methods: A wide range concentration of arsenic trioxide were cultured with (vascular smooth muscle cell.VSMC) with different time,cell growth curve, MTT assay, electron microscopy detection, inverted phase contrast microscope, HE staining were used to study cell activity and morphologic changes. Results: After culturing with AsO2, VSMC present cells number decrease,fat granule increase,and apoptotic featuresect. Electron microscopic appearance of VSMC exhibiting membrane integrity, chromatin condensation,apoptotic body formation,ect. Conclusion:AsO2 can induce apoptosis of VSMC
【CateGory Index】: R96
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Chinese Journal Full-text Database 1 Hits
1 Li Hui,Zhang Yanbin,Song Hao,Xiao Fei,Zhang Zhuoqi,Li Dongye.West China Second Hospital,Sichuan University,Sichuan 610041,China;Study on the Mechanisms of Arsenic Trioxide-induced Vascular Smooth Muscle Cells Apoptosis in vitro[J];Journal of Medical Research;2010-10
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5 YANG Wei~*, GE Jun-bo, LIU Hong-ling, AN Yi, LIU Xue-bo,TIAN Ye, QU Xiu-fen, LI Wei-min, HUANG Yong-lin. * The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China;Arsenic trioxide eluting stents to prevent restenosis of injured iliac arteries in rabbits[J];Chinese Journal of Cardiology;2006-01
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