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《Chinese Journal of Clinical Medicine》 2006-02
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Correlation Analysis of Auditory Evoked Potentials Index and Bispectral Index with Midazolam-induced Sedation

GE Shengjin XUE Zhanggang ZHUANG Xinliang,et al Department of Anesthesia,Zhongshan Hospital,Fudan University,Shanghai 200032;Department of Anesthesia,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080  
Objective:To study the correlationship of the autoregressive model with exogenous input extracted auditory evoked potentials index (A-line ARX-index, AAI), bispectral index (BIS) with midazolam-induced sedation. Methods: Fourteen ASA Ⅰ-Ⅱ adult patients, undergone elective gynecological surgery under low-thoracolumbar epidural anesthesia were studied. An intravenous bolus dose of midazolam (0. 5mg) was administered every 5 minutes until the score level 1 of the observer's assessment of the alertness/ sedation scale (OAA/S) reached. AAI, BIS were monitored on different OAA/S score levels and their correlation with midazolam-induced sedation was analyzed. Results: During the onset phase. Both AAI and BIS were distinctly reduced as patients' OAA/S scores decreased, and correlated with sedation significantly (the coefficient of Spearman's rank correlation r=0. 973,0. 945,P0.001). AAI correlated better than BIS (P 0. 05) with the scores. During the recovery phase, all patients got awake (OAA/S scores 4-5) abruptly, and AAI, BIS increased speedily. Conclusion: Both AAI and BIS can assess midazolam-induced sedation quantitatively and accurately.
【CateGory Index】: R96
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