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《Chinese Journal of Clinical Medicine》 2006-02
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Protective Effects of Ulinastatin on Liver in Cardiopulmonary Bypass during Open Heart Surgery

BAO Haijun GAO Baishun LI Tiancheng,et al.Department of Cardiac Surgery,the First Hospital of Lanzhou University,Lanzhou 730000  
Objective:To investigate the effects of ulinastatin (UTI) on liver in cardiopulmonary bypass during open heart surgery. Methods: A total of thirty patients under cardiopulmonary bypass during open heart surgery were randomly divided into study group (groupA,n= 15) and control group (group B,n= 15 ). The patients in group A received ulinastatin (UTI 15000UI/kg) and those in group B did not receive it. Blood samples were withdrawn from central vein for the measurements of tumor necrosis factor-α(TNF-α),interleukin-8(IL-8) and -6(IL-6),alanine aminotransferase(ALT) and total bilirubin(TB) before the operation,30 min after aortic and cardiac cannulation,1h and 6h after the aortic declamping and 24h after the operation by radioimmunity and automatic biochemistry analysator. Results: In group A, the leves of TNF-α. IL-8, IL-6, ALT and TB were lower than those in group B at each time point during and after the operation. Conclusion: UTI can protect liver function in cardiopulmonary bypass during open heart surgery.
【CateGory Index】: R614
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