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《Chinese Journal of Clinical Medicine》 2006-02
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Treatment of Severe Acute Pancreatitis with Continuous Infusing Ulinastatin through a Catheter Placed in Regional Artery

ZHANG Zhiqiang CHEN Xiaoli Department of General Surgery,the People's Hospital of Anyang City in Henan Province,Anyang 455000  
Objective:To evaluate the efficacy of continuous infusing ulinastatin(UTI) through a catheter, placed in regional artery, in patients with severe acute pancreatitis. Methods: Forty-three cases of severe acute pancreatitis (SAP) were divided into treatment group(20 cases) and control group(23 cases). Treatment group was treated with interventional therapy immediately after diagnosed. Selding's method was used,briefly placing a catheter in the artery, irrigating the inflamed area of the pancreas, and continuously infusing UTI; while in control group. UTI was infused by intra-venous infusion. The efficacy between the two groups was compared. Results: The value of blood amylase, urine amylase. blood sugar, blood uria nitrogen and white blood cell count were significantly lower but that of blood calcium was higher in treatment group than those in control group on the 3rd and 6th day after the treatment ( P0.05,P0.01,P0.05 respectively). There was a significantly shorter duration of abdominal pain, abdominal distension and tenderness in treatment group than in control group (all P0.01). The complications rate was lower in treatment group than in control group(P0. 05). Conclusion: The treatment of severe acute pancreatitis by continuous infusing UTI through a catheter placed in regional artery offers better efficacy and lower complications rate than by intra-venous infusing UTI.
【CateGory Index】: R657.5
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