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《Chinese Journal of Clinical Medicine》 2006-02
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Clinical and Pathological Analysis of Angiolymphoid Hyperplasia with Eosinophilia in 13 Cases

CHEN Lianjun YANG Qinping DAI Yan Department of Dermatology,Huashan Hospital,Fudan University,Shanghai 200040;Department of Dermatology,Jiangdu Municipal People's Hospital in Jiangsu Province,Jiangdu 25200  
Objective:To analyze the clinical presentation, pathological feature , therapy and outcome of angiolymphoid hyperplasia with eosinophilia (ALHE). improve the recognition of this rare disease. Methods: We reviewed the clinical findings , pathologic changes and outcome of 13 cases with ALHE from Jan. 1999 to Dec. 2005. Results: Clinically, it was characterized by solitary or multiple, red to brown cutaneous papules or nodules with no lymphadenopathy, usually located on the head and neck. It was easy to be misdiagnozed. However, the characteristics of histological features including a proliferation of blood vessels, distinctive endothelial cells and infiltration with lymphocytes and eosinophils are helpful to establish the diagnosis. Surgical excision was good to solitary lesion while multiple lesions were resistant to conventional therapies and easy to recur. Conclusion: Histopathological examination is necessary for the diagnosis of ALHE. Despite of recurrence, surgical removal of the lesions has demonstrated the best results.
【CateGory Index】: R758.6
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