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《Chinese Journal of Clinical Medicine》 2017-03
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Advances on aging of growth differentiation factor 11

ZHAO Su-jie;LU Yi;WU Xiao-yan;Department of Gerontology,Huashan Hospital,Shanghai Medical College of Fudan University;  
Growth differentiation factor 11(GDF11),a member of the transforming growth factorβ(TGF-β)family,is widely expressed in many tissues.GDF11 regulates multiple developmental processes by reversing cell cycle arrest and reverses the aging process of many tissues including heart,skeletal muscle,brain,bone and blood vessels.In this article,we review the role of GDF11 in aging considering the TGF-βfamily signaling pathway and the mechanism of GDF11 in growth and development.
【Fund】: 上海市科学技术委员会重点项目科技创新行动(10431904000)~~
【CateGory Index】: R339.38
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