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《Chinese Journal of Clinical Medicine》 2018-04
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Prognostic value of mucosa-associated lymphoid tissue International Prognostic Index in Chinese patients with mucosa-associated lymphoid tissue lymphoma

LI Jing;WEI Zheng;LIANG Li-fan;ZHANG Xue-jiao;ZHANG Yi-an;LIU Peng;Department of Hematology,Zhongshan Hospital,Fudan University;  
Objective:To explore the applicability of mucosa-associated lymphoid tissue(MALT)International Prognostic Index(MALT-IPI)in Chinese patients with MALT lymphoma and compare the prognostic value of different risk stratification methods for MALT lymphoma.Methods:A total of 129 patients with MALT lymphoma diagnosed and treated in Zhongshan Hospital,Fudan University between January 2007 and December 2016 were analyzed retrospectively.Survival analysis was performed according to the MALT-IPI and IPI scoring system.Results:The median age of patients was 56 years old(range,22-82 years old).Fifty-three patients(41.1%)had gastric MALT lymphoma.Lung involvement was found in25.6% cases.More than half of patients presented with limited stage disease(71 patients stageⅠ-Ⅱ,55.1%)at diagnosis,and the remaining 58(44.9%)patients were in stage Ⅲ-Ⅳ.The median follow-up period was 26 months(range,1-378 months).The 5-year overall survival(OS)rate and 5-year progression-free survival(PFS)rate were 90.23% and 69.41%,respectively.For IPI scoring system,the 5-year PFS rate in low-,low-intermediate-,high-intermediate/high-risk groups were74.8%,65.2%,and 58.2%,respectively(P=0.125);while for the MALT-IPI model,the 5-year PFS rate in low-,intermediate-,high-risk groups for MALT-IPI were 82.4%,58.4%,and 47.2%,respectively(P=0.003).Conclusions:MALT-IPI is suitable for Chinese MALT lymphoma patients.In comparison with IPI,MALT-IPI would be a more proper prognostic index for the prediction of OS and PFS in patients with MALT lymphoma.
【Fund】: 国家自然科学基金(81570123);; 上海市卫生系统优秀学科带头人项目(2017BR033);; 上海市卫生和计划生育委员会科研课题(201440390)~~
【CateGory Index】: R733.1
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