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《Chinese Journal of Clinical Medicine》 2018-04
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Expression of YAP and FOXP1 mRNA in hepatocellular carcinoma and its influence on prognosis of patients with hepatocellular carcinoma

CHEN Yuan;ZHOU Yuan;YIN Bi-hui;LI Huai-liang;HOU Wei-xiao;ZHOU Yi-long;SHAO Bing-feng;ZHANG Su-qing;XU Ai-bing;ZHANG Yi-xin;Department of Surgery,Nantong Tumour Hospital,Nantong University;Department of Clinical Medicine,Graduate School,Nantong University School of Medicine;  
Objective:To investigate the expression of Yes-associated protein(YAP)and Forkhead-box P1(FOXP1)mRNA in hepatocellular carcinoma(HCC)and its influence on patients' disease-free survival(DFS).Methods:Real-time quantitative reverse transcriptase polymerase chain reaction(RT-PCR)was used to detect the mRNA expression of YAP,FOXP1 mRNA in paraffin-embedded tissues of 114 HCC patients.Regression analysis was performed to estimate the effect of YAP and FOXP1 mRNA expression levels on the DFS time of HCC patients.Results:The mRNA expression levels of YAP and FOXP1 were significantly associated with tumor diameter,TNM stage,and AFP(P0.05).The expression level of YAP was directly correlated with that of FOXP1(r=0.76,P0.000 1).A univariate analysis showed that tumor differentiation,TNM stage,gross classification,α-fetoprotein,HBV infection,YAP and FOXP1 expression were predictors of DFS in HCC patients.Furthermore,multivariate Cox proportional hazards regression analysis indicated that HBV infection and YAP/FOXP1 co-expression were independent prognostic factors for HCC(P0.05).Conclusions:High expression of FOXP1 and YAP mRNA in HCC tissue might affect the DFS prognosis of patients with HCC.
【Fund】: 南通市指令性科技计划(MS22015010);; 南通市指导性科技计划(HS149069 HS149073);; 南通市卫计委青年基金(WQ2015047);; 江苏省南通市卫计委重点病种的临床规范化诊疗项目(MS32015028);江苏省南通市卫计委医学重点学科建设项目(YY201207)~~
【CateGory Index】: R735.7
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