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《Chinese Journal of Clinical Medicine》 2018-04
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Expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma

PENG Rui;HUANG Xiao-yong;CAI Jia-bin;KE Ai-wu;SHI Guo-ming;BAI Dou-sheng;The Second Xiangya Hospital,Central South University;Institute of Liver Cancer,ZhongshanHospital,Fudan University;The Subei People's Hospital,Yangzhou University;  
Objective:To investigate the expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma(ICC). Methods: The expression of TRIM44 and MMP9 in 87 ICC patients were analyzed by immunohistochemistry.And the clinical significance of TRIM44 and MMP9 were investigated by Kaplan-Meier and Cox regression models.Results:The expressions of TRIM44 and MMP9 were upregulated in tumor tissues of ICC.TRIM44 was positively associated with MMP9 expression in ICC(P0.001).TRIM44 expression was significantly correlated with the lymph node metastasis(P=0.014),and MMP9 was significantly correlated with the tumor size,AFP concentration,and lymph node metastasis(P0.05).Simultaneous overexpression of TRIM44 and MMP9 suggested poor prognosis of ICC patients.Conclusions: TRIM44 and MMP9 are overexpressed in ICC and are closely related to each other.The high expressiones of both suggest poor prognosis of ICC patients.
【Fund】: 江苏省“六大人才高峰”项目(2014-WSW-076)~~
【CateGory Index】: R735.8
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