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《Chinese Journal of Clinical Medicine》 2018-04
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Clinical features of patients with invasive micropapillary carcinoma of breast among multiple centers in China

NI Xiao-jian;KUANG Xia-ying;ZHOU Ping;ZHANG Hong-wei;ZHU Wei;Department of General Surgery,Zhongshan Hospital,Fudan University;Department of Breast Surgery,the First Affiliated Hospital,Sun Yat-Sen University;Department of Breast Surgery,the Third Hospital of Nanchang;  
Objective:To investigate the clinicopathologic features of invasive micropapillary carcinoma(IMPC)of breast.Methods:The clinical and pathologic features of 205 cases of breast IMPC during June 1993 to July 2017 were retrospectively analyzed.A total of 410 patients with invasive ductal carcinoma excluding IMPC in the same period were selected as control.Results:There were statistically significances in the age distribution,tumor size,lymph node metastasis rate,histological grading,progesterone receptor(PR)and human epidermal growth factor receptor 2(HER2)expression,value of Ki-67,molecular classification between IMPC and IDC patients(P0.05).However,estrogen receptor(ER)status was not statistically significant.Conclusions:IMPC is a rare type of breast cancer with aggressive growth.Patients with IMPC were usually younger,with larger tumors,but higher lymph node metastasis rate,histological grade,hormone receptor positive and HER2 negative rates.There was a higher proportion of Luminal B breast cancer in IMPC,and lower in triple negative breast cancer.
【Fund】: 国家自然科学基金(81702586 81502267);; 复旦大学附属中山医院青年基金(2016ZSQN59)~~
【CateGory Index】: R737.9
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