DISTRIBUTION, EXCRETION AND BIOLOGICAL TRANSFORMATION OF AN ANALOG OF LUTEINIZING HORMONE-RELEASING HORMONE (LHRH-A) IN RAT
Wu Manping Zhuang Qingqi Chen Beifan Li Huijie(Department of Biochemistry, School of Pharmacy,Shanghai Medical University, 200032)Zhu Gengen Du Liang Huang Living(Department of Radio-Pharmacy, Shanghai Medical University)Li Qiaoyun (Department of Mathemetics, Shanghai Medical University)
The present study ,successive to our previous report, was under-taken to determine the tissues distribution, excretion, biotransformation and metabolism of LHRH-A in rat. Its tissue distribution after administration would be arranged in an ascending order of radioactivity : kidney, liver and glandular tissues.The results of urine HPLC and plasma TLC suggested that only the catabolic products without the original LHRH-A would be found in urine. 12 minutes after intravenous administration,the greater part of LAHR-A was-found transforming into a plasma binding from instead of a free form.
【CateGory Index】： R96