The pharmacokinetics and relative bioavailability of gemfibrozil tablets in healthy volunteers
Wu Linhua,Sun Kaoxiang.Hu Junru.et al (The Institute of Clinical Pharmacy, Harbin Medical University,Harbin 150086)
AIM:To study pharmacokinetics and bioavailability of gemfibrozil in 8 young healthy volunteers. METHODS: Acoording to the cross - over design,each volunteer was o-rally given gemfibrozil tablets and capsule in single dosage respectively,and the plasma concentrations in different time were determined by reversed-phase high-performance liquid method. RESULTS :The data were fitted by MCPKP program. The pharmacokinetics of gemfibrozil tablets and capsule could be described by open single compartment model. The Tmax, Cmax and AUCo~∞ of two products were (1. 61±0. 49)and (1. 66±0. 47)h,(37. 28±9. 71)and (29. 97±5. 58μg/ml;(28. 48±24. 36)and (119. 55±19. 48μg/(h · ml) respectively. CONCLUSION: The relative bioavailiability of gemfibrozil talbets were 107-26% compared with capsule.
【CateGory Index】： R96