Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Pharmacy》 1998-01
Add to Favorite Get Latest Update

The comparison study of pharmacokinetics for single-dose convention and sustained-release of albuterol sulfate

Zhou Xianbiao.Shen Jingfang.Zhen Lin, et al (Division of Clinical Pharmacy of Renji Hospital,Shanghai Second Medical University, Shanghai 200001)  
AIM:To study the pharmacokinetics and relative bioavailability of a sustained-release formulation of albuterol. METHODS: Albuterol was determined following a single and multiple oral dose given to volunteers in an open randomized crossover study. RESULTS: After a single oral dose the peak levels in plasma averaged(9. 70 ± 2. 94)and (18. 52 ±3. 31)ng/ml at (4. 60±0. 63)and (2. 39±1. 07)h and AUC were (102. 41 ± 16. 98)and (109. 15±20. 86)ng/(h · ml) for sustained-release and conventional formulations respectively. The bioavailability of sustained-release formulation was 93. 82%. The peak-trough fluctuation index (FI) for the two formulations were (0. 524±0. 205)and (0. 637±0. 159) respectively. CONCLUSION: The result showed that two formulations were bioequivalence.
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved