The pharmacokinetics of cefoxitin in Chinese healthy volunteers
Zhao Minghua,Qiu Yiqun.Gu Jiaqin.et al (Department of Clinical Pharmacy and Clinical Pharmacology.Shanghai Jingan District Central Hospital, Shenghai 200050)
AIM: To study the disposition of domestic cefoxitin. METHODS: Eight healthy volunteers were infused with 2g domestic cefoxitin. Serum concentration of cefoxitin was determined by high performance liquid chromatography. RESULTS:Its pharmacokinetic parameters were calculated by two compartment model in all subjects :Tmax= (92. 07 ± 21. 95) μg/ml,T1/2β=(54.29±8. 01)min,Cl= (0. 38 ±0. 08)L/min, Vd = (13. 27 ± 3. 69)L,AUC = (90. 34±19. 59)μg/(h · ml) ,K10= (0. 029 ±0. 0036)/min. These parameters were similar to those reported in foreign journals. CONCLUSION: The results indicate that there is no significant differences between domestic and foreign formulations.
【CateGory Index】： R969