The study of relationship between dihydroquinidine serum concentration and effect of treatment for 40 patients with atrial fibrillation
Su Lequn,Li Hongjian,Zhou Liaosheng,et al (Shangdong Province Qianfoshan Hospital, Jinan 250014)
AIM:To study the relationship between dihydroquinidine serum concentration and effect of treatment for artial fibrillation. METHODS:The serum concentrations of 10 patients with atrial fibrillation were measured with TDx after taking tablet of dihydroquinidine. RESULTS: T1/2(ka) was (2. 22 ± 1. 25) h, T1/2was was (8. 22 ± 4. 25) h, Tmax was (6. 99 ± 3.03)h,Cmax was (0. 6±0. 41) μg/ml ,AUC was (9. 99±5. 96)μg/(h · ml) and the serum concentration at steady state peak and bottom in 40 patients with atrial fibrillation were measured. CONCLUSION: The effective serum concentration for dihydroquinidine was 0. 82 ~ 1. 20μg/ml.
【CateGory Index】： R541.75