Renal effect of lacidipine in patients with essential hypertension
Guo Jizhen,Qian Wenqi,Sun Bing,et al (Shanghai Second Medical University,Shanghai Institute of Hypertension, Clinical Hypertension Department of Ruijin Hospital, Shanghai200025)
AIM:To evaluate the renal effect of new dihydropyridine of calcium antagonists, lacidipine in essential hypertensive patients,METHODS:Eighteen inpatients with moderate essential hypertension [male 16,female 2, average age(52 ±6)a]were submitted to a low-salt diet (20mmol of Na/day for 5 days),a high-salt diet (260mmol of Na/day for 7 days) and normal salt diet (160mmol of Na/day for 4 weeks) with the administration of lacidipine(4~6mg/d)after 1~2 weeks untreated. After above periods,all patients were examined with laboratory investigation that included glomerular filtration rates (GFR), renal plasma flows (RPF), urinary microalbumin excretion rate (UMAE)and urinary ratinal binding protein excretion rate (URE). RESULTS: ①UMAE decreased significantly under low-salt diet (P0. 01). ② GFR and RPF had increased tendency but not significantly change after the administration of lacidipine. ③ UMAE decreased significantly (from 26. 2mg/24h to 15. 0mg/24h.P0. 05)while GFR had increased tendency [from (127±43 ) to (143 ± 36)ml/min], CONCLUSION :Lacidipine did not impair renal function but decrease UMAE which seems to be not correlated with renal hemodynamics.
【CateGory Index】： R544.1