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《Chinese Journal of Clinical Pharmacy》 2001-01
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Influence on peripheral blood figure from combined amphotericin B and flucytosine in patients with cryptococcus meningitis

Xie Chunying 1, Li Jianguo 2, Xie Shibin 2, Cai Shaoxian 1 ( 1Department of Pharmacy, The Sixth Hospital, GuangZhou 510655; 2Department of Infectious Disease, The Third Affiliated Hospital, Sun Yat Sen Unviersity of Medical Sciences, Guan  
AIM: To observe the influence on peripheral blood figure by amphotericin B (AMB) combined with flucytosine (5 FC) in the treatment of the patients with cryptococcus meningitis. METHODS: Thirty patients with cryptococcus meningitis treated by AMB combined with 5 FC were evaluated. Their peripheral blood figures were observed regularly before and after treatment. RESULTS: The results showed that 80% (24/30) of patients appeared mild or middle anaemia, the incidence rate of neutropenia and thrombocytopenia were 13 3% (4/30) and 6 7% (2/30) respectively. CONCLUSION: The influence on peripheral blood figure from AMB combined with 5 FC in the treatment of the patients with cryptococcus meningitis is anaemia. The change of peripheral blood figure is not the main reason to stop treating.
【CateGory Index】: R519
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