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《Chinese Journal of Clinical Pharmacy》 2001-01
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Comparison of nifedipine controled-release tablet vs amlodipine on heart rate variability in hypertensive patients

Gu Wei, Zheng Bosheng, Chen Yang, Gong Ling, Yang Shuping (Cardiovascular Department of Huadong Hospital, Shanghai 200040)  
AIM: To evaluate the effects of 2 calcium channel blockers, nifedipine controled release tablet and amlodipine on heart rate variability in hypertensive patients. METHODS: Forty patients with essential hypertension were randomized to nifedipine group ( n= 20) or amlodipine group ( n= 20). After 2 wk run in period, patients were treated with either nifedipine 30-60 mg/d or amlodipine 5-10 mg/d for 8 wk. Time and frequency domain measures of heart rate variability were obtained from 1 h Holter recording, before and after 8 wk of treatment. RESULTS: Blood pressure values decreased with 2 drugs. Time domain measures of HRV, including the average R R intervals (AVGR R), standard deviation of the averages of normal R R intervals (SDAR R), the coefficient of variation (CV), the mean differences of standard deviation of the average R R intervals (SD), standard deviation of differences between adjacent R R intervals (SDSD) and the square root of the mean squares of differences between adjacent R R intervals (rmSASD), comparable at baseline, were unchanged in 2 groups. Frequency domain measures of HRV, including low frequency power (LF 0 025-0 1 Hz), medium fequency power (MF 0 1-0 2 Hz), high frequency power (HF 0 2-0 3 Hz), the low to high frequency power [R(LF/HF)], comparable at baseline, were unchanged in 2 groups. CONCLUSION: Both nifedipine and amlodipine have no unfavorable effect on cardiac autonomic control in treating hypertension.
【CateGory Index】: R544.1
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