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《Chinese Journal of Clinical Pharmacy》 2001-01
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Pharmacokinetics and relative bioavailability of granisetron hydrochloride capsules in healthy volunteers

Li Tongling 1, Pang Yinuo 1, Chen Zelian 1, Wang Zhixiao 1, Jia Yurong 1, Cheng Qiang 2 ( 1Department of Clinical Pharmacy, School of Pharmacy, West China University of Medical Sciences, Chengdu 610041; 2Department of Pharmacology, I  
AIM: To study the pharmacokinetics and relative bioavailability of granisetron hydrochloride capsules and tablets in healthy volunteers. METHODS: The granisetron hydrochloride concentration in serum was determined by high performance liquid chromatography (HPLC) method after a single oral dose (12 mg) of capsule or tablet was administered to 12 healthy male volunteers respectively in an open randomized cross over test. RESULTS: After being processed by 3P87 pharmacokinetic program, the experiment data showed that the pharmacokinetic parameters of the capsules and the tablets were AUC 0→t : (133 7±61 8) and (131 1±57 4) (ng·h)/ml; AUC 0→∞ : (150 9±69 8) and (150 6±67 5) (ng·h)/ml; t max : (2 9±0 4) and (2 9±0 3) h; c max : (24 6±9 3) and (24 6±0 7) ng/ml respectively. There were no significant differences between AUC and c max of these 2 preparations ( P 0 05). The relative bioavailability of granisetron hydrochloride capsules was F 0→t : (101 5±11 2)% and F 0→∞ : (100 2±13 5)%. CONCLUSION: These 2 preparations are bioequivalent.
【CateGory Index】: R96
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