Therapeutic effects of benquinin hydrochloride on hemorrhagic shocked rats
Sun Xiaohong, Ding Rigao, Du Xianlin, Zhang Xiancheng (Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850)
AIM: For evaluation of the therapeutic effects of benquinin hydrochloride on hemorrhagic shocked rats. METHODS: Fifteen hemorrhangic shocked male rats were divided into 3 different groups ( n =5): saline control, anisodamine treated group and benquinin hydrochloride treated group, time courses of the changes on 4 important life indexes such as mean arterial blood pressure (MABP), respiratory rate were recorded. RESULTS: Anisodamine (5 0 mg/kg, iv) had decreases in the microvascular perfusion of the rat ear, MABP, respiratory rate and exchanged air volume of the shocked rats at 5 min when compared with the control, followed by slow increases at later time points, were observed during the experimental period. Benquinin hydrochloride (1 mg/kg, iv) had no effect on the MABP when compared with the control group, but it immediately increased the microvascular perfusion in the rat ear very significantly for the first 15 min and kept at an comparatively high level, being nearly equal to that of the treatment with anisodamine. Benquinin hydrochloride also increased the respiratory rate, exchanged air volume in the shocked rats. CONCLUSION: Although the rat viability and the death time were nearly the same between the anisodamine and benquinin hydrochloride treated groups, the results suggest that benquinin hydrochloride may have increased the life quality of the hemorrhagic shocked rats by its speedy modification of the microcirculation and its enhancement of the respiratory function.