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《Chinese Journal of Clinical Pharmacy》 2006-01
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Effects of ulinastatin on the release of proinflammatory cytokines in patients undergoing open heart operation

Ye Lingjun~1,Zhang Weifang~2(~1Department of Internal Medicine,Ruoheng Hospital,Wenling 317507 China;~2 ICU,1st Affliated Hospital of Zhejiang University,Hangzhou 310003,China)  
AIM To investigate the effects of ulinastatin on the release of proinflammatory cytokines in patients undergoing open heart operation.METHODS Twenty eight patients undergoing elective open heart surgery with cardiopulmonary bypass(CPB) were randomly divided into 2 groups: ulinastatin group (group U,n=14) and control group(group C,n=14).In group U,ulinastatin 12 000 U·kg~(-1) was received intravenously after anesthesia induction,but in group C,instead of normal saline.Blood samples were withdrawn from central vein for the measurements of interleukin-6(IL-6) and interleukin-8(IL-8),after anesthesia induction(T_0),30 min following champing(T_1),reperfusion 1h(T_2),reperfusion 3 h(T_3) and reperfusion 6 h(T_4).RESULTS The levels of IL-6,IL-8 showed no difference between groups after anesthesia induction(P0.05).After CPB,the levels of IL-6 and IL-8 increased compared with the T_0 and T_1(P0.05) in both groups.Compared with those in group C,the level of IL-6 and IL-8 in the group U were lower significantly(P0.05) in the time at T_2,T_3,and T_4.CONCLUSION Ulinastatin may significantly inhibit the proinflammatory cytokine(IL-6,IL-8) release and protect the organ from inchemia-reperfusion injury.
【CateGory Index】: R614
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