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《Chinese Journal of Clinical Pharmacy》 2006-01
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Effects of ulinastatin on the release of proinflammatory cytokines in patients undergoing open heart operation

Ye Lingjun~1,Zhang Weifang~2(~1Department of Internal Medicine,Ruoheng Hospital,Wenling 317507 China;~2 ICU,1st Affliated Hospital of Zhejiang University,Hangzhou 310003,China)  
AIM To investigate the effects of ulinastatin on the release of proinflammatory cytokines in patients undergoing open heart operation.METHODS Twenty eight patients undergoing elective open heart surgery with cardiopulmonary bypass(CPB) were randomly divided into 2 groups: ulinastatin group (group U,n=14) and control group(group C,n=14).In group U,ulinastatin 12 000 U·kg~(-1) was received intravenously after anesthesia induction,but in group C,instead of normal saline.Blood samples were withdrawn from central vein for the measurements of interleukin-6(IL-6) and interleukin-8(IL-8),after anesthesia induction(T_0),30 min following champing(T_1),reperfusion 1h(T_2),reperfusion 3 h(T_3) and reperfusion 6 h(T_4).RESULTS The levels of IL-6,IL-8 showed no difference between groups after anesthesia induction(P0.05).After CPB,the levels of IL-6 and IL-8 increased compared with the T_0 and T_1(P0.05) in both groups.Compared with those in group C,the level of IL-6 and IL-8 in the group U were lower significantly(P0.05) in the time at T_2,T_3,and T_4.CONCLUSION Ulinastatin may significantly inhibit the proinflammatory cytokine(IL-6,IL-8) release and protect the organ from inchemia-reperfusion injury.
【CateGory Index】: R614
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHU Lin(The Fourth Hospital of Baotou,Baotou 014030,China);The Therapeutic Effects of Evaluation of Ulinastatin on Acute Pancreatitis[J];Journal of Baotou Medical College;2008-05
2 TIAN Yan-feng1,LI Yong2,ZHAO Qun2,FAN Li-qiao2,ZHAO Wen-jiang2,XU Bao-li2,SONG Zhen-chuan2,KUANG Gang2,DONG Zhi-ming3,ZHANG Qing-fu4 1Department of General Surgery,4Departmant of Burn Surgery,First Hospital of Hebei Medical University,Shijiazhuang 050031,China;2Department of Surgery,3Institute of Oncology,Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Effect of ulinastatin on intestinal mucosal barrier function of rats with obstructive jaundice[J];Journal of Southern Medical University;2007-07
3 WANG Xiuli.Department of Medical,Traditional Chinese Medicine Hospital of Xinzheng,Xinzheng 451100,China;Ulinastatin in the treatment of acute pancreatitis in 42 cases[J];Clinical Medicine;2010-03
4 LIANG Lunchang,LIANG Maojin,TAN Qiping,CHEN Weiquan.Department of Internal Medicine,People's Hospital of Luoding,Luoding 527200,China;Efficacy of low molecular heparin,ulinastatin combined with glutathione in treatment of systemic inflammatory response syndrome[J];Clinical Medicine;2010-06
5 GONG Peng,WANG Zhong yu,TAI Peng jun,et al.Department of General Surgery of The First Affiliated Hospital of Dalian Medical University.Dalian,China,116011);PREVENTION AND TREATMENT FOR POST ERCP PANCREATITIS[J];Journal of Hepatobiliary Surgery;2004-02
6 LIU Naxin, LIU Cunli, SHI Hongqi, et al. Department of General Surgery, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000;Influence of Ulinnastatin and Dexamehasone on blood TNF-α, IL-10 and GR in rats with acute necrotizing pancreatitis[J];Journal of Hepatopancreatobiliary Surgery;2008-05
7 Cao Weihong Chai Jiake Yang Hongming,Burn,Institute,a first Affiliated Hospital to the PLA General,Hospital,Beijing 100037;The influence of high dose ulinastatin on blood coagulation function in severely burned patients and its significance[J];Infection.Inflammation.Repair;2005-03
8 YANG Qi-gang1,LUO Xiao-ming1,ZHANG Qiong2(1.Department of Critical Care Medicine;2.Department of Cardiac Surgerical Intensive Care Unit,First Affiliated Hospital,Anhui Medical University,Hefei 230022,China);Clinical efficiency of ulinastatin treatment on severe acute pancreatitis[J];Anhui Medical and Pharmaceutical Journal;2011-09
9 XIE pa,XIA Ai-xiao,HE Ren(Zhejiang Province Taizhou Hospital medicament branch,Linhai 317000,China);Clinical Observation on ulinastatin in treatment of acute pancreatitis[J];Strait Pharmaceutical Journal;2010-11
10 HUANG Yongpeng,XU Xiaopeng,WANG Xiaojie,et al(Gaoming District People's Hospital of Foshan,Guangdong Foshan 528500,China);Lung Protective Mechanical Ventilation Combined Ulinastati for the Treatment of Acute Lung Injury[J];Hebei Medicine;2010-07
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