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《Chinese Journal of Clinical Pharmacy》 2011-01
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Early effects of Huangbanmingmu capsule on retinal degeneration in rats induced by N-methyl-N-nitrosourea

WANG Yandong,ZHEN Dongqin,YAO Xiangchao,TANG Xilan,YE Chengtian(Department of Pharmacy,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China)  
AIM To observe the early antagonistic effects of Huangbanmingmu capsule on retinal degeneration induced by N-methyl-N-nitrosourea(MNU) in SD rats.METHODS Female SD rats of 43-day-old were randomly divided into control group,model control group and Huangbanmingmu capsule group.Huangbanmingmu capsule was irrigated into rats with intragastric administration in Huangbanmingmu capsule group for continuous 7 d twice one day.Control group and model group were given equal distilled water.SD rats in 7 d after treatment received a single injection of 40 mg·kg~(-1) MNU,ip in model group and Huangbanmingmu capsule group;while control group was given equal normal saline. Changes of a wave and b wave of electroretinogram(ERG) were observed in 12,24,48 and 72 h after MNU injection. The rats were killed in 7 d after MNU treatment and histopathologic changes were observed.RESULTS The difference of the average amplitude of ERG a wave and b wave was not significant between different time in control group.The average amplitude of ERG a wave and b wave gradually decreased after MNU treatment in model group.Huangbanmingmu capsule could evidently inhibit lose of a wave and b wave.The histopathologic injury of rat retina in Huangbanmingmu capsule group was lighter than in model control group by means of transmission electron microscopy and light microscopy.CONCLUSION Huangbanmingmu capsule has early antagonistic effects on retinal degeneration induced by MNU in SD rats.
【Fund】: 广东省中医药管理局科研项目(编号2009165)
【CateGory Index】: R285.5
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