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《Chinese Journal of Clinical Pharmacy》 2011-01
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Effect of bulleyaconitin A on the chemotaxis of mouse peritoneal macrophages

JIANG Long~1,ZHANG Yunyi~1,LI Hong~1,WENG Weiyu~2(1 Department of Pharmacology,School of Pharmacy,Fudan University,Shanghai 201203,China;2 Department of Pharmacy,East China University of Science and Technology, Shanghai 200237,China)  
AIM To determine the effect of bulleyaconitin A(BLA) on the chemotaxis of mouse peritoneal macrophages.METHODS Peritoneal macrophages were isolated from adult male mice.The main groups were as follows: blank control group,MCP-1 group and complement activated product group.Each group contained some subgroups which treated with solvent and BLA(80,40,20,10 and 5μg·L~(-1)).The chemotaxis of peritoneal macrophage was assayed by using 24 well transwell permeable supports.RESULTS Peritoneal macrophages treated with MCP-1 or complement activated product showed a greater chemotaxis index than blank control group(P0.01);BLA(80,40,20,10 and 5μg·L~(-1)) given alone exhibited no significant effect on the chemotaxis(P0.05).However,BLA(80,40,20,10 and 5μg·L~(-1)) inhibited the increase of chemotaxis index induced by MCP-1 or complement activated product(P0.01).CONCLUSION BLA could inhibit the chemotaxis of macrophages induced by MCP-1 or complement activated product.However,BLA has no significant effect on chemotactic function of peritoneal macrophages in the absence of chemoattractant.
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 Weng Weiyu 1, Xu Huinan 1, Li Hong 2, Shen Teng 1, Zhang Jianfang 1, Shao Li 1, Qian Lihua 1 ( 1Department of Pharmaceutics, 2Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China);Skin permeability and anti-inflammatory analgesic activities of bulleyaconitine A liposomes[J];Chinese Journal of Clinical Pharmacy;2003-03
2 LU Ye~(a#) HAN Li~(a#) LI Hong~(a#) WENG Wei-yu~b (a Department of Pharmacology,b.Department of Pharmacy,School of Pharmacy,Fudan University,SHANGHAI 200032,China);Inhibitory effect of bulleyaconitine A on some immune function in Balb/c mice[J];Chinese Journal of New Drugs and Clinical Remedies;2007-10
3 Zhang Yuanchao, Yang Qingrui, Yin Hongen, Liu Wenbo, Yin Guofu, Zhang Desheng (1st. Affiliated Hospital of Shandong Medical University Jinan 250012);Clinical Trial on Osteoarthritis and Rheumatoid Arthritis with Bulleyaconitin A[J];PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA;2000-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Yu Changxi;Huang Lingyan;Tang Xican(1.Department of Pharmocology,Fujian Medical College,Fuzhou,3500042.shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,200031);Structure-Activity Relationship of Yunaconitine and Its Analogues on Analgesia[J];;1996-01
2 Wang Fengpeng(Department of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041, China);A Deliberation on Methodology of Modernization of Traditional Chinese Medicines Based on the Research and Development of New Drugs from "Cao Wu"[J];Progress in Chemistry;2009-01
3 LIN Ling-yun 1,CHEN Qiao-hong 2,WANG Feng-peng 2* (1.Mental Health Center,Shantou University,Shantou 515063,China;2.West China School of Pharmacy,Sichuan University,Chengdu 610041,China);Advances in pharmacological activities of norditerpenoid alkaloids[J];West China Journal of Pharmaceutical Sciences;2004-03
4 FENG Yi,SHANG Fei,XU De-sheng(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China);Preparation of Bulleyaconitine A microemulsion and investigation of its physicochemical properties[J];West China Journal of Pharmaceutical Sciences;2007-05
5 ZHAO Wen-ming (Department of Pharmacy,Liaoning Medical University,Jinzhou 121001,China);Preparation of injectable bulleyaconitine A in situ gels[J];Chinese Journal of Pharmaceutics;2009-04
6 XIAO Ruo-lan,XU Hui,DENG Yi-hui (School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Degradation kinetic of bulleyaconitine A[J];Journal of Shenyang Pharmaceutical University;2008-08
7 LU Ye~(a#) HAN Li~(a#) LI Hong~(a#) WENG Wei-yu~b (a Department of Pharmacology,b.Department of Pharmacy,School of Pharmacy,Fudan University,SHANGHAI 200032,China);Inhibitory effect of bulleyaconitine A on some immune function in Balb/c mice[J];Chinese Journal of New Drugs and Clinical Remedies;2007-10
8 TANG Xi-Can, LIU Xue-Jun, LU Wei-Hua, WANG Mao-De and LI Ai-Ling (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai);STUDIES ON THE ANALGESIC ACTION AND PHYSICAL DEPENDENCE OF BULLEYACONITINE A[J];Acta Pharmaceutica Sinica;1986-12
9 JIAN Jiang-bo~1,YUAN Yuan~2,YANG Bai-can~1*,LIU Chang-sheng~2(1.Shanghai University of TCM,Shanghai 201203;2.Engineering Research Center for Biomedical Materials of Ministry of Education,Insitute of Biomaterials,East China University of Science and Technology,Shanghai 200237,China);Analgesic and anti-inflammatory activities of brucine nano-liposome for local use on skin[J];Chinese Traditional Patent Medicine;2006-12
10 LU Wei-gen(1,2),CHEN Ting-ting1,REN De-quan2(1.Shanghai Institute of Pharmaceutical Industry,Shanghai 200437;2.East China University of Science and Technology,Shanghai 200237,China);Determination of entrapment efficiency of bulleyaconitine A multivesicular liposomes[J];Chinese Traditional Patent Medicine;2007-06
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Weng Weiyu 1, Xu Huinan 1, Li Hong 2, Shen Teng 1, Zhang Jianfang 1, Shao Li 1, Qian Lihua 1 ( 1Department of Pharmaceutics, 2Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China);Skin permeability and anti-inflammatory analgesic activities of bulleyaconitine A liposomes[J];Chinese Journal of Clinical Pharmacy;2003-03
2 LI Hong,ZHANG Yun-yi,HUANG Xi-yi,SUN Ya-nan,JIA Yong-feng,LI Duan (Department of Pharmacology,School of Pharmacy,Fudan University,SHANGHAI 200032,China);Induction and characteristics of systemic lupus erythematous syndrome in mice[J];Chinese Journal of New Drugs and Clinical Remedies;2004-08
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4 Hong LI, Yun-yi ZHANG, Ya-nan SUN, Xi-yi HUANG, Yong-feng JIA, Duan LI2 Department of Pharmacology, Schoolof Pharmacy, Fudan University, Shanghai 200032, China;Induction of systemic lupus erythematosus syndrome in BALB/c mice by immunization with active chromatin[J];中国药理学报(英文版);2004-06
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