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《Chinese Journal of Clinical Pharmacy》 2011-05
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Antitumor effect of elemene combined with fluorouracil in mice bearing hepatocar-cinoma H22 cells-derived tumor

XU Wencui~1,REN Shuangyi~2(1 Department of Traditional Chinese Medicine and Western Medicine,2 Department of Surgery,The Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China)  
AIM To observe the antitumor effects of elemene combined with fluorouracil(5-FU) on H22 tumor cell in mice.METHODS After injecting H22 hepatoma cell into their right axila,35 mice were randomly and equally divided into 5 groups,which had been treated for 10 d as follows:elemene-higher group(100 mg?kg~(-1)),elemene-lower group(50 mg·kg~(-1)).5-FU group(20 mg·kg~(-1)),elemene(50 mg·kg~(-1)) combined with 5-FU(20 mg·kg~(-1)) group, and control group:normal saline(0.2 mL each mouse).The weight of each animal and the volume of its tumor during treatment were recorded.The inhibiting rate was caculated after 10 d.And the differences of tumor was observed by HE staining histologically.RESULTS Volumes of tumor of the 4 treatment groups were less than those of control group significantly after the 5th day.Effects on weight of the combined and 5-FU groups were more significant.Under the light microscope,the condensation and fragmentation of cells in mice xenograft were observed by HE staining.CONCLUSION Elemene can effectively inhibit the growth of H22 tumor.Furthermore,it can be used as an adjuvant agent with 5-FU.
【CateGory Index】: R735.7
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