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《Chinese Journal of Clinical Pharmacy》 2011-05
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Analysis of risk factors and suspected drugs of drug-induced liver disease in inpatients population

JIANG Huifang~1,CHENG Nengneng~1,DU Wenmin~2,CHEN Binyan~1(1 Department of Pharmacology,School of Pharmacy, Fudan University,Shanghai 201203,China;2 Shanghai Center for Adverse Drug Reactions Monitoring, Shanghai 200233,China)  
AIM To study the incidence rate,risk factors and suspected drugs of drug-induced liver disease in inpatients population.METHODS Based on Shanghai inpatients drug utilization database we concluded in our study those patients whose alanine aminotransferase value was twice recorded and set the alanine aminotransferase value over 60 U·L~(-1) as the assess standard for drug-induced liver disease.We used Logistic regression analysis method to analyze the effects of age,sex,drug,length of hospital stay and baseline alanine aminotransferase value on drug-induced liver disease, and calculated the likelihood of suspected drug in inducing liver disease.RESULTS A total of 3 030 inpatients fell into the selective criteria,171(5.61%)cases was diagnosed as drug-induced liver disease.Medication type was a risk factor.The suspected drugs involved all kinds of drugs,and among these involved drugs the Chinese traditional medicine had the highest cited frequency,the antibacterial agents the second.A total of 220 drugs were suspected as liver disease inducing drug,sulfamethoxazole and ketamine had the higher likelihood.CONCLUSION To avoid drug-induced liver disease,medication should be attached to liver function monitoring when inpatients are applied with multi-drugs or drug with liver toxicity.
【CateGory Index】: R595.3
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