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Clinical characteristics of drug fever related to piperacillin compound preparation treatment

ZHU Suyan,HU Yijian(Department of Pharmacy,Ningbo No.1 Hospital of Zhejiang Province,Ningbo 315010,China)  
AIM To understand clinical characteristics of drug fever caused by peperacillin compound preparation and provide the basic information for diagnosis of patients with drug fever.METHODS In this study,47 hospitalized patients who had drug fever during anti-infective treatment between 2007 and 2010 were enrolled.RESULTS Eosinophile granulocyte increased for most patients who had drug induced fever.Most of drug induced fever was developed between 8 and 14 d after medication treatment and the accumulated medication dosage between 1.6 g·kg-1 and 2.7 g·kg-1.CONCLUSION The change of eosinophile granulocyte could provide the information of drug induced fever diagnosis and the occurrence of drug fever has correlation with the course of treatment and the accumulated medication dosage.
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