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Effect of Novolin N combined with glimepiride tablets in treatment of type 2 diabetes

WANG Jianping,ZHAO Wei(Internal Medicine,Tinglin Hospital of Shanghai Jinshan District,Shanghai 201505, China)  
AIM To observe the clinical efficacy and safety of Novolin N combined with glimepiride tablets in the treatment of patients with type 2 diabetes of simple oral hypoglycemic medication with poor effect.METHODS Sixtyfour patients with type 2 diabetes of simple oral hypoglycemic medication with poor effect were randomly divided into 2 groups:the treatment group was given Novolin N and glimepiride tablets,and the control group was given Novolin 30R. After 12 weeks,the levels of fasting plasma glucose(FPG),2-hours postprandial glucose(2hPPG),glycosylated hemoglobin AIc(Hb_(A1C))were determined.RESULTS FPG,2hPPG and Hb_(A1C)significantly decreased in 2 groups(P 0.05).Hb_(Alc)and 2hPPG did not significantly decrease before treatment,but they significantly decreased after 12 weeks' treatment(P0.05).Novolin N combined with glimepiride tablets group significantly decreased in frequency of hypoglycemia than Novolin 30R group(P0.05).CONCLUSION Novolin N combined with glimepiride tablets in the treatment of patients with type 2 diabetes of simple oral hypoglycemic medication with poor effect are safe and effective,which shows the superior efficacy,with less frequency of hypoglycemia.
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