Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Investigation of the stability of the dexamethasone sodium phosphate injection and mecobalamin injection in sodium chloride injection

HUANG Taomin,CHEN Nianzu,WANG Donglei,LAI Yonghua,MA Qin,YAN Jinchao(Department of Pharmacy, Eye,Ear,Nose,and Throat Hospital Affiliated to Fudan University,Shanghai 200031,China)  
AIM To investigate the stability of dexamethasone sodium phosphate injection and mecobalamin injection in sodium chloride injection.METHODS Dexamethasone sodium phosphate and mecobalamin were determined by RP-HPLC method at 4℃and normal temperature under natural illumination and nonillumination within 12 h.The appearance of the solution was observed and its pH value was determined.RESULTS No significant change was found in the terms of the appearance and the contents of the mixed solution,the changes of pH value were not more than 1.0 under nonillumination within 12 h.No significant change was found in the terms of the content of dexamethasone sodium phosphate under illumination within 12 h.However,more than 50%mecobalamin was degraded under natural illumination within 5 min.CONCLUSION The dexamemasone sodium phosphate injection and mecobalamin injection should not be simultaneously put in the sodium chloride injection for intravenous infusion.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved