Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Simultaneous determination of the content of acetaminophen and sodium benzoate in acetaminophen oral liquid preparation by gas chromatography

LIU Guangqian~1,MO Xuanyong~2,YAO Guoxin~1(1 Department of Pharmacy,Dongguan Tungwah Hospital,Dongguan 523010,China;2 Guoyao Quality Inspection Center in Dongguan City,Dongguan 523010,China)  
AIM To establish a gas chromatography method for determining the content of acetaminophen and sodium benzoate content in acetaminophen oral liquid preparation.METHODS Shimadzu GC-17AA gas chromatograph used SE-54 fused silica capillary column(30 m×0.25 mm×0.5μm).The detector was hydrogen flame detector (FID),carrier gas was high purity N_2.The FID temperature was 300℃,injection volume was 1μL,gas split ratio was 20:1,the initial column temperature was 50℃,reached to 120℃with the speed of 25℃·min~(-1)and keeping for 3 min, reached to 170℃with the speed of 8℃·min~(-1)and keeping for 10 min,reached to 250℃with the speed of 10℃·min~(-1) and keeping for 5 min.RESULTS The linear range of acetaminophen and sodium benzoate was 39.87-398.7 mg·L~(-1) (r=0.999 3)and 2.006-6.018 mg·L~(_1)(r=0.999 1),respectively.The regression equation was A=3 552 039ρ+ 57 673,A=450 650ρ+41 921.The average recovery(n=9)was 97.28%(RSD=0.87%)and 95.15%(RSD= 1.32%),respectively.CONCLUSION The method is simple,rapid,specific,and can be used to effectively control the content of acetaminophen and sodium benzoate in acetaminophen oral liquid preparation.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved