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《Chinese Journal of Clinical Pharmacy》 2013-01
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Individual administration model for sodium valproate established using artifitial neural network

Wang Jun;Fu Cuixiang;Wu Weiming;Wang Zengshou;Xu Hongxiang;Department of Pharmacy,The 2nd Affiliated Hospital of Wenzhou Medical College;School of Pharmacy Wenzhou Medical College;  
AIM To build a predictive model constructed by artificial neural network,and to provide individual administration reference for sodium valproate.METHODS The cases of the 200 outpatients' children with epilepsy were collected.Influence factors on concentration and dosage of sodium valproate were analyzed and model factors were determined.A scheme of two chained dosage prediction models was established by CA-BP algorithm,and some samples were used to validate the model.RESULTS A tentative program for individual administration was compiled.The predicted plasma concentration of sodium valproate for 30 patients demonstrated that the deviations of 21 samples were below 15%,those of 6 samples were between 15%-20%,and those of 3 samples exceeded 20%.CONCLUSION A individual administration research of sodium valproate could be attempted by artificial neural network.
【CateGory Index】: R96
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 Chen Hao,Yu Jiangnan 1,Xiang Bingren(Center for instrumental analysis,China Pharmaceutical University, Nanjing210009; 1Department of Pharmacy, ZhenjiangMedical College, Zhenjiang 212001);Current new application of Artificial neural network(ANN) in clinical pharmacy[J];Chinese Journal of Modern Applied Pharmacy;2002-02
2 JIANG De-chun, WANG Li, LU Wei1 Department of Pediatrics of First Hospital, 1 Pharmacy School, Peking University, Beijing 100034, China;Setting up population pharmacokinetics/pharmacodynamics model of VPA in children with epilepsy by NONMEM software[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2005-11
3 YU Jun-xian1,SHI Li-min1,WANG Ru-long1,LI Shan2,XIA Jie2,CHENG Sheng1,WEN Ai-ping1,WEI Hong-tao1(1.Department of Clinical Pharmacology,Beijing Friendship Hospital Affiliated to the Capital University of Medical Sciences,Beijing 100050,China;2.Department of Mathematics & Computer,Nanjing Medical University,Nanjing 210029,China);Individual Administration Model for Cyclosporine A Established Using Artificial Neural Network[J];Chinese Pharmaceutical Journal;2010-12
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Wang Qinghua,Tang Tian,Wang Qingqing,Liu Yaqiong,Lin Hui,Huang Guorong,Xiong Hongyan(Department of Military Epidemiology,College of Military Preventive Medicine,Third Military Medical University,Chongqing,400038,China);Development of an intelligent model for diagnosis of common rash and fever illness in children[J];Journal of Third Military Medical University;2011-23
2 LIU Ying WANG Li(1.Peking University School of Oncology,Bei]ing Cancer Hospital & Institute,Beijing 100036,China;2.Peking University First Hospital,Beijing 100034,China);Significance of population pharmacokinetics in pediatric drug therapy[J];Journal of Pediatric Pharmacy;2008-03
3 QIU Feng,HE Xiao-jing, ZHAO Li-mei,SUN Ya-xin (Department of Pharmacy,Sheng Jing Hospital of China Medical University,Shenyang 110004,China);Prediction the plasma concentration of valproate in patients with epilepsy by artificial neural network[J];The Chinese Journal of Clinical Pharmacology;2012-02
4 HUANG Zhao-ming1,ZHONG Cheng2,LI Xiao-ru1(1.No.1 Affiliated Hospital,Guangxi Medical University,Nanning 530022,China;2.School of Computer Science and Electronic Information,Guangxi University,Nanning 530004,China);Simulation study of respiratory disease diagnosis based on BP neural network[J];Journal of Hefei University of Technology(Natural Science);2012-03
5 ;丙戊酸钠与左乙拉西坦治疗小儿癫痫60例疗效分析[J];Chinese Journal of Ethnomedicine and Ethnopharmacy;2010-12
6 ZHANG Peng WU Peng ZHANG Huijian CHEN Zhuangfei ZHENG Shaobin LIU Chengshan(Deparment of Urology,Nanfang Hospital of Southern Medical University,Guangzhou,510515,China);Prediction of success rate for single ESWL-treated renal calculi by artificial neural network[J];Journal of Clinical Urology;2012-11
7 ZHANG Zhi-cheng,LI Xiao-xue,FENG Wan-yu(The First Affiliated Hospital,China Medical University,Shenyang 110001,China);Population pharmacokinetics of sodium valproate in epileptic patients[J];Journal of Shenyang Pharmaceutical University;2009-12
8 WANG Hong-hong,MAO Gui-fu,TAN Qiang(Hospital for Maternity and Child Healthcare of Liuzhou,Liuzhou 545001,China);The research overview on blood concentration monitoring of sodium vedproate[J];Qilu Pharmaceutical Affairs;2012-10
9 SUN Zhi-an ZHANG Cui-xian ZHU Chen-chen YUE Xi-shun;Forecasting Model for Data of NMR Based on BP Neural Network[J];Microcomputer Information;2008-15
10 QIAN Jia,ZHENG Qin,CHENG Xing-mei,YUE Peng-fei,WU Zhen-feng,HU Peng-yi1.Key Laboratory of Modern Preparation of TCM,Ministry of Education,,Jiangxi Nanchang 330004,China;2.Shan Dong Traditional Chinese Medical University,Shan Dong Jinan,250355 China;The progress of PK-PD model and the method of status analysis in Chinese traditional medicine[J];Journal of Jiangxi University of Traditional Chinese Medicine;2011-01
China Proceedings of conference Full-text Database 2 Hits
1 GUO Yu-jiao,WANG Wei-qing,SHAO Zhi-gao,ZHAO Ping,ZHANG Hong-wen The First Affiliated Hospital of NanJing Medical University,Nanjing 21009;Analysis of serum concentration of Anti-epileptic in 2009[A];[C];2010
2 Yang xiaoxi1 Tang Zhijiao2 Huang Tianlai3 Wang Yong2 Yi fengmin1 Su Shurong4 Tian Weiqun1*(1 Food and Drug Safety Evaluation Center of Wuhan University; 2 Animal Biosafety Level 3 Laboratory of Wuhan University; 3 International Software School of Wuhan University, 4 Mathematics and Statistics School of Wuhan University,Wuhan,430071);Application of BP Artificial Neural Network Modeling in Compatibility Optimization of YiShen Compound Mixture[A];[C];2010
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WU Ju, ZHONG Youquan, XIE Xiaoli, et al (Children's hospital of Chengdu 610017);Clinical analysis of antiepileptic therapy with individuated-dose valproate in child[J];Journal of Pediatric Pharmacy;2002-04
2 (△WANG Lan, LIU Liang,/ △Faculty of forensic medicine, Tongji Medical College of Huazhong University of Science and Technology ,Wuhan 430030 China);Application of artificial neural network in forensic science[J];Chinese Journal of Forensic Medicine;2005-03
3 ZHOU Lu,SU Yi,ZUO Zhi-li,ZHAO Cai-bin,XIA Kun-hua Department of Pharmaceutical Engineering,College of Chemical Engineering,Sichuan University,Chengdu 610065,China;Qantitative structure-pharmacokinetic relationship of antimicrobial agents drug plasma protein binding[J];West China Journal of Pharmaceutical Sciences;2003-01
4 Deng Qingshan(School of Software,Jiangxi University of Finance and Economics,Nanchang 330013);Clustering on Gene Expression Data[J];Computer Engineering and Applications;2005-35
5 CAO Hui,XI Bin,MI Hong College of Science and Technology,Xiamen University,Xiamen,Fujian 361005,China;Application of new clustering algorithms in gene expression data[J];Computer Engineering and Applications;2007-18
6 BAI Yao - hui, CHEN Ming (Automatic College, Northwestern Polytechnical University, Xi'an Shanxi 710072, China);Visualizing Clusters Based on the Serf- Organizing Map[J];Computer Simulation;2006-01
7 LI Yan-yun1,LI-rui2,ZHANG Sheng- nian2(1.School of Public Health,Fudan University,Shanghai 200032,China;2.Shanghai Municipal c\ Center for Disease Control and Prevention,Shanghai 200336,China);Articial Neural Network and its Perspective on Disease Screening[J];Journal of Environmental & Occupational Medicine;2006-01
8 HE Jia 1,HE Xian min 2,ZHANG Zhi jian 1 (Department of health statistics, Second Military Medical University, Shanghai 200433,China; 2.Shanghai Eastern Hepatobiliary Surgery Hospital,Shanghai 200438,China);The prediction of the survival time of hepatectomy patients with artificial neural network method[J];Application of Statistics and Management;2002-04
9 CAO Xian qing,MU Yong ge (Chongqing University of Medical Sciences, Chongqing 400016,China);Artificial Neural Networks Technology Applications for Medicine Research[J];Journal of Modern Clinical Medical Bioengineering;2003-01
10 Rui Jianzhong Lu Jianfeng Lin Shusen Department of Clinical Pharmacology,Jinling Hospital, Nanjing 210002;NONMEM Program and Its Application in Clinical Pharmacology[J];;1997-03
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