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Research of toxicity of alkaloids from Sophora alopecuroides

Li Shenghu1,He Shenghu2(1.Ningxia Professional Technical College,Yinchuan 750002,China;2.School of Agriculture,Ningxia University,Yinchuan 750021,China)  
Alkaloids were extracted with chloroform and n-butanol respectively from Sophora alopecuroides treated by 90% ethanol with combination of ultrasound.Toxicities of alkaloids of chloroform and n-butanol extractions were researched by taking mice as test animals.LD50 of chloroform extraction component was 178.89 mg/kg and LD50 of n-butanol extraction component was 209.06 mg/kg.Bleeding of internal organs of mice was main pathological change of toxication induced by alkaloids from Sophora alopecuroides.The target organs were liver,kidney and lungs.
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